Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007.

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dc.contributor.authorGurav, Yogesh K
dc.contributor.authorTandale, Babasaheb V
dc.contributor.authorJadi, Ramesh S
dc.contributor.authorGunjikar, Rashmi S
dc.contributor.authorTikute, Sanjaykumar S
dc.contributor.authorJamgaonkar, Aniruddha V
dc.contributor.authorKhadse, Ravindra K
dc.contributor.authorJalgaonkar, Suresh V
dc.contributor.authorArankalle, Vidya A
dc.contributor.authorMishra, Akhilesh C
dc.date.accessioned2011-12-01T08:52:31Z
dc.date.available2011-12-01T08:52:31Z
dc.date.issued2010-10
dc.description.abstractBackground & objectives: An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features. Methods: AES cases among children <15 yr, from Nagpur division, hospitalized between June-September 2007, were investigated. Serum and cerebrospinal fluid (CSF) were tested for IgM antibodies against Chandipura virus (CHPV) and Japanese encephalitis virus (JEV) and for CHPV RNA by RT-PCR. Partial N gene sequences were used for phylogenetic analysis. Virus isolations were attempted in rhabdomyosarcoma (RD) cell line. Sandflies were collected, pooled and tested for CHPV RNA by RT-PCR. Results: A total of 78 AES cases were recorded in children <15 yr of age. Case fatality ratio was 43.6 per cent. Male to female ratio was 1:1.2. Chandipura (CHP) was confirmed in 39 cases. CHPV RNA was detected in both CSF and serum specimens of 2 cases and in serum of 22 cases. Phylogenetic analysis showed 99.98 – 100 per cent nucleotide identity in the sequences studied. Anti-CHPV IgM antibodies were detected in CSF of 2 cases and in serum of 8 cases. Seroconversion to anti-CHPV IgM antibodies was observed in 5 cases. Clinical manifestations of CHP cases (n=38) were fever (100%), convulsion (76.3%), altered sensorium (34.2%), headache (23.7%), vomiting (44.7%) and diarrhoea (23.7%). CHPV RNA was detected in one of two pools of sandflies from affected locality. Interpretation & conclusions: Chandipura virus was confirmed as the aetiological agent of this acute encephalitis outbreak with high case-fatality among children.en_US
dc.identifier.citationGurav Yogesh K, Tandale Babasaheb V, Jadi Ramesh S, Gunjikar Rashmi S, Tikute Sanjaykumar S, Jamgaonkar Aniruddha V, Khadse Ravindra K, Jalgaonkar Suresh V, Arankalle Vidya A, Mishra Akhilesh C. Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007. Indian Journal of Medical Research. 2010 Oct; 132(4): 395-399.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135600
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2010/October/8.pdfen_US
dc.subjectAcute encephalitis syndromeen_US
dc.subjectChandipura virusen_US
dc.subjectchildrenen_US
dc.subjectoutbreaken_US
dc.subjectsandflyen_US
dc.subject.meshAnimals
dc.subject.meshAntibodies, Viral --blood
dc.subject.meshAntibodies, Viral --cerebrospinal fluid
dc.subject.meshBase Sequence
dc.subject.meshCell Line, Tumor
dc.subject.meshChild
dc.subject.meshCluster Analysis
dc.subject.meshDNA Primers --genetics
dc.subject.meshDisease Outbreaks
dc.subject.meshEncephalitis, Viral --epidemiology
dc.subject.meshEncephalitis, Viral --pathology
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshInsect Vectors --virology
dc.subject.meshMale
dc.subject.meshMolecular Sequence Data
dc.subject.meshNucleocapsid Proteins --genetics
dc.subject.meshPhylogeny
dc.subject.meshPsychodidae --virology
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshRhabdoviridae Infections --epidemiology
dc.subject.meshRhabdoviridae Infections --pathology
dc.subject.meshSequence Analysis, DNA
dc.subject.meshVesiculovirus --genetics
dc.titleChandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007.en_US
dc.typeArticleen_US
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