Vulnerable plaques, inflammation and newer imaging modalities.

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dc.contributor.authorBhatia, Ven_US
dc.contributor.authorBhatia, Ren_US
dc.contributor.authorDhindsa, Sen_US
dc.contributor.authorVirk, Aen_US
dc.date.accessioned2003-10-31en_US
dc.date.accessioned2009-06-02T11:29:17Z
dc.date.available2003-10-31en_US
dc.date.available2009-06-02T11:29:17Z
dc.date.issued2003-10-31en_US
dc.description.abstractCurrently, inflammation is considered to be the central player in the pathogenesis of atherosclerosis. It leads to the formation of multiple plaques in the arterial beds including coronary vasculature. Recent studies using the latest imaging techniques have shown that in patients with acute coronary syndromes (ACS) multiple plaques are ruptured and have thrombus formation on them. Various factors make these plaques unstable, these include structural components of plaque like thin fibrous cap, high lipid content of the plaque core and inflammation, both localized and generalized. It has been shown that most of the ACS are caused by plaques causing non-critical stenosis as seen on traditional X-ray angiography. Also, the phenomenon of remodelling makes angiography a poor technique for plaque visualization. Hence newer modalities are required to identify these "vulnerable plaques". Intravascular ultrasound (IVUS), thermography and Magnetic Resonance Imaging (MRI) are a few such promising techniques. Here we review the invasive and non-invasive modalities that can be helpful in the identification of these plaques before they become unstable and cause ACS, and also the available therapies to stabilize these plaques.en_US
dc.description.affiliationDepartment of Internal Medicine, SUNY, Buffalo, NY, USA. vbhatia@buffalo.eduen_US
dc.identifier.citationBhatia V, Bhatia R, Dhindsa S, Virk A. Vulnerable plaques, inflammation and newer imaging modalities. Journal of Postgraduate Medicine. 2003 Oct-Dec; 49(4): 361-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/116252
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAngioscopyen_US
dc.subject.meshCoronary Angiographyen_US
dc.subject.meshCoronary Stenosis --diagnosisen_US
dc.subject.meshCoronary Thrombosis --pathologyen_US
dc.subject.meshCoronary Vessels --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammationen_US
dc.subject.meshThermographyen_US
dc.subject.meshUltrasonography, Interventionalen_US
dc.titleVulnerable plaques, inflammation and newer imaging modalities.en_US
dc.typeJournal Articleen_US
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