Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.

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dc.contributor.authorSarker, Shafiqul Aen_US
dc.contributor.authorPant, Nehaen_US
dc.contributor.authorJuneja, Lekh Ren_US
dc.contributor.authorHammarström, Lennarten_US
dc.date.accessioned2007-12-12en_US
dc.date.accessioned2009-05-27T03:49:50Z
dc.date.available2007-12-12en_US
dc.date.available2009-05-27T03:49:50Z
dc.date.issued2007-12-12en_US
dc.descriptionJournal of Health, Population, and Nutrition.en_US
dc.description.abstractThe role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting.en_US
dc.description.affiliationICDDR,B, GPO Box 128, Dhaka 1000, Bangladesh. sasarker@icddrb.orgen_US
dc.identifier.citationSarker SA, Pant N, Juneja LR, Hammarström L. Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin. Journal of Health, Population, and Nutrition. 2007 Dec; 25(4): 465-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/719
dc.language.isoengen_US
dc.source.urihttps://www.icddrb.org/pub/publication.jsp?classificationID=30&typeClassificationID=2en_US
dc.source.urihttps://www.icddrb.org/publication.cfm?classificationID=30&pubID=9107en_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Sucklingen_US
dc.subject.meshAntibodies, Viral --biosynthesisen_US
dc.subject.meshAntigens, Viral --immunologyen_US
dc.subject.meshDiarrhea --immunologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEgg Yolk --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization, Passiveen_US
dc.subject.meshImmunoglobulins --immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRotavirus --immunologyen_US
dc.subject.meshRotavirus Infections --immunologyen_US
dc.titleSuccessful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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