Immunopharmacological studies on Picrorhiza kurroa Royle ex Benth. Part VI: Effect on anaphylactic activation events in rat peritoneal mast cells.

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dc.contributor.authorPandey, B Len_US
dc.contributor.authorDas, P Ken_US
dc.contributor.authorGambhir, S Sen_US
dc.date.accessioned1989-01-01en_US
dc.date.accessioned2009-06-01T06:07:29Z
dc.date.available1989-01-01en_US
dc.date.available2009-06-01T06:07:29Z
dc.date.issued1989-01-01en_US
dc.description.abstractMechanism of inhibition of mast cell anaphylaxis by P. kurroa-extract (PK) treatment in rats was investigated. Mast cell-IgE binding, assessed from induction of passive sensitization, was not affected. Calcium-independent early activation events in mast cell anaphylaxis indicated on inhibitory influence of PK-treatment. Inhibition of membrane-protease release by PK-treatment was suggested by study of gastric secretion and exhibition of saturable synergism with Di-isopropyl fluoro phosphate on inhibition of anaphylactic degranulation. pH-independence of mast cell stabilizing effect negates any PK-influence on phospholipid transmethylation. The results complement findings of earlier studies on indirect effects of PK through alteration of membrane structure/function.en_US
dc.description.affiliationDepartment of Pharmacology, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationPandey BL, Das PK, Gambhir SS. Immunopharmacological studies on Picrorhiza kurroa Royle ex Benth. Part VI: Effect on anaphylactic activation events in rat peritoneal mast cells. Indian Journal of Physiology and Pharmacology. 1989 Jan-Mar; 33(1): 47-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107143
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnaphylaxis --immunologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens --immunologyen_US
dc.subject.meshGastric Juice --drug effectsen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshIsoflurophate --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMast Cells --drug effectsen_US
dc.subject.meshPeptide Hydrolases --analysisen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleImmunopharmacological studies on Picrorhiza kurroa Royle ex Benth. Part VI: Effect on anaphylactic activation events in rat peritoneal mast cells.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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