Pulmonary surfactants and their role in pathophysiology of lung disorders.

Simple item page
dc.contributor.authorAkella, Aparna
dc.contributor.authorDeshpande, Shripad B
dc.date.accessioned2013-07-25T10:16:44Z
dc.date.available2013-07-25T10:16:44Z
dc.date.issued2013-01
dc.description.abstractSurfactant is an agent that decreases the surface tension between two media. The surface tension between gaseous-aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. The pulmonary surfactant is produced by the alveolar type-II (AT-II) cells of the lungs. It is essential for efficient exchange of gases and for maintaining the structural integrity of alveoli. Surfactant is a secretory product, composed of lipids and proteins. Phosphatidylcholine and phosphatidylglycerol are the major lipid constituents and SP-A, SP-B, SP-C, SP-D are four types of surfactant associated proteins. The lipid and protein components are synthesized separately and are packaged into the lamellar bodies in the AT-II cells. Lamellar bodies are the main organelle for the synthesis and metabolism of surfactants. The synthesis, secretion and recycling of the surfactant lipids and proteins is regulated by complex genetic and metabolic mechanisms. The lipid-protein interaction is very important for the structural organization of surfactant monolayer and its functioning. Alterations in surfactant homeostasis or biophysical properties can result in surfactant insufficiency which may be responsible for diseases like respiratory distress syndrome, lung proteinosis, interstitial lung diseases and chronic lung diseases. The biochemical, physiological, developmental and clinical aspects of pulmonary surfactant are presented in this article to understand the pathophysiological mechanisms of these diseases.en_US
dc.identifier.citationAkella Aparna, Deshpande Shripad B. Pulmonary surfactants and their role in pathophysiology of lung disorders. Indian Journal of Experimental Biology. 2013 Jan; 51(1): 5-22.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147532
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/15282en_US
dc.subjectAdult respiratory distress syndromeen_US
dc.subjectHyaline membrane diseaseen_US
dc.subjectInfant respiratory distress syndromeen_US
dc.subjectLamellar bodiesen_US
dc.subjectLungsen_US
dc.subjectPhosphatidylcholineen_US
dc.subjectSurfactant associated proteinsen_US
dc.subject.meshAnimals
dc.subject.meshBiophysics --methods
dc.subject.meshHomeostasis
dc.subject.meshHumans
dc.subject.meshLipids --chemistry
dc.subject.meshLung --metabolism
dc.subject.meshLung Diseases --physiopathology
dc.subject.meshModels, Biological
dc.subject.meshModels, Genetic
dc.subject.meshPhosphatidylcholines --metabolism
dc.subject.meshPhosphatidylglycerols --metabolism
dc.subject.meshPulmonary Surfactants --metabolism
dc.titlePulmonary surfactants and their role in pathophysiology of lung disorders.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijeb2013v51n1p5.pdf
Size:
381.81 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Experimental Biology