Prevalence and pattern of nodal metastasis in pT4 gingivobuccal cancers and its implications for treatment.

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dc.contributor.authorNarendra, H
dc.contributor.authorTankshali, R A
dc.date.accessioned2013-01-16T03:22:27Z
dc.date.available2013-01-16T03:22:27Z
dc.date.issued2010-07
dc.description.abstractContext: The pattern of nodal spread in oral cancers is largely predictable and treatment of neck can be tailored with this knowledge. Most studies available on the pattern are from the western world and for early cancers of the tongue and floor of the mouth. Aims: The present study was aimed to evaluate the prevalence and pattern of nodal metastasis in patients with pathologic T4 (pT4) buccal/alveolar cancers. Settings and Design: Medical records of the patients with pT4 primary buccal and alveolar squamous cell carcinomas treated by single-stage resection of primary tumor and neck dissection at Gujarat Cancer and Research Institute (GCRI), Ahmedabad, a regional cancer center in India, during September 2004 to August 2006, were analyzed for nodal involvement. Materials and Methods: The study included 127 patients with pT4 buccal/alveolar cancer. Data pertaining to clinical nodal status, histologic grade, pT and pN status (TNM classification of malignant tumors, UICC, 6th edition, 2002), total number of nodes removed, and those involved by tumor, and levels of nodal involvement were recorded. Statistical analysis was performed using the Chi-square test. Results: Fifty percent of the patients did not have nodal metastasis on final histopathology. Occult metastasis rate was 23%. All of these occurred in levels I to III. Among those with clinically palpable nodes, level V involvement was seen only in 4% of the patients with pT4 buccal cancer and 3% of the patients with alveolar cancer. Conclusions: Elective treatment of the neck in the form of selective neck dissection of levels I to III is needed for T4 cancers of gingivobuccal complex due to a high rate of occult metastasis. Selected patients with clinically involved nodes could be well served by a selective neck dissection incorporating levels I to III or IV.en_US
dc.identifier.citationNarendra H, Tankshali R A. Prevalence and pattern of nodal metastasis in pT4 gingivobuccal cancers and its implications for treatment. Indian Journal of Cancer. 2010 Jul-Sept; 47(3): 328-331.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144360
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=3;spage=328;epage=331;aulast=Narendraen_US
dc.subjectElective and therapeutic neck dissectionsen_US
dc.subjectgingivobuccal cancersen_US
dc.subjectlymph node spreaden_US
dc.subject.meshAdenocarcinoma, Bronchiolo-Alveolar --pathology
dc.subject.meshAdenocarcinoma, Bronchiolo-Alveolar --physiopathology
dc.subject.meshAdenocarcinoma, Bronchiolo-Alveolar --surgery
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLung Neoplasms --epidemiology
dc.subject.meshLung Neoplasms --pathology
dc.subject.meshLung Neoplasms --physiopathology
dc.subject.meshLung Neoplasms --surgery
dc.subject.meshLymph Nodes --pathology
dc.subject.meshLymph Nodes --surgery
dc.subject.meshLymphatic Metastasis
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMouth Neoplasms --epidemiology
dc.subject.meshMouth Neoplasms --pathology
dc.subject.meshMouth Neoplasms --physiopathology
dc.subject.meshMouth Neoplasms --surgery
dc.subject.meshNeck Dissection
dc.subject.meshNeoplasm Staging
dc.subject.meshNeoplasms, Squamous Cell --epidemiology
dc.subject.meshNeoplasms, Squamous Cell --pathology
dc.subject.meshNeoplasms, Squamous Cell --physiopathology
dc.subject.meshNeoplasms, Squamous Cell --surgery
dc.subject.meshPrevalence
dc.titlePrevalence and pattern of nodal metastasis in pT4 gingivobuccal cancers and its implications for treatment.en_US
dc.typeArticleen_US
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