Expression of adenosine deaminase and 5'-nucleotidase in artificially induced deciduoma in rat and hamster.

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dc.contributor.authorFarheen, Shabanaen_US
dc.contributor.authorSrivastava, V M Len_US
dc.contributor.authorMehrotra, P Ken_US
dc.date.accessioned2009-05-28T11:33:11Z
dc.date.available2009-05-28T11:33:11Z
dc.date.issued2002-08-25en_US
dc.description.abstractEnzymes adenosine deaminase (ADA) and 5-nucleotidase (5-'NT) are known to play active role in tissue/cell proliferation and differentiation. To validate this the two enzymes were studied in artificially induced deciduoma of rat and hamster. The deciduoma was induced by traumatizing one of the uterine horns of progesterone primed animals. Non traumatized horn served as control. The animals were later maintained on progesterone, given alone (Gr.I) or conjointly with estrogen (Gr.II). The weight of each uterine horn was recorded to determine the formation of deciduoma. There was no marked difference between the weights of traumatized and control horn on day 2 post-traumatization (PT), but a progressive rise was noticed after this day in both species. The ADA activity however differed, day and species wise. While in the rats of Gr.I it was low in the traumatized horn on all the days, in the hamsters it was remarkably high from day 2 to 6 PT. In the rats of Gr.II also the activity though was low in the traumatized horn, but on day 2 and 4 only; on day 6 and 7 PT it increased markedly. In hamster, on the contrary, again the enzyme activity was remarkably high on all the three days. The 5'-NT activity, however, did not show any marked difference between the two horns under Gr.I and II in both species. It was rather high in the control horn of each group. The results suggest: (I) the progesterone alone though produces a significant rise in the uterine weight of traumatized horn in both species, the ADA activity increases only in hamster, (2) under the conjoint treatment also the enzyme activity remains high in hamster; and (3) the activity of enzyme 5'-NT does not alter during the deciduoma formation in both the species.en_US
dc.description.affiliationDivision of Endocrinology, Central Drug Research Institute, Post Bag No. 173, Lucknow 226 001, India.en_US
dc.identifier.citationFarheen S, Srivastava VM, Mehrotra PK. Expression of adenosine deaminase and 5'-nucleotidase in artificially induced deciduoma in rat and hamster. Indian Journal of Experimental Biology. 2002 Aug; 40(8): 889-93en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56874
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.mesh5'-Nucleotidase --metabolismen_US
dc.subject.meshAdenosine Deaminase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDeciduoma --drug effectsen_US
dc.subject.meshEstrogen Antagonists --pharmacologyen_US
dc.subject.meshEstrogens --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshProgesterone --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshUterus --drug effectsen_US
dc.titleExpression of adenosine deaminase and 5'-nucleotidase in artificially induced deciduoma in rat and hamster.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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