A study on lipid profile in thyroid dysfunction
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Date
2023-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Mrs Dipika Charan of MedScience (India) Publications
Abstract
Background: Thyroid diseases are among the most common endocrine disorders worldwide. Thyroid hormones play a key role in regulating the synthesis, metabolism, and mobilization of lipids. Levels of circulating lipids may alter in thyroid dysfunction. Aim and Objectives: The aim of the study was to find out the alterations of lipid levels in thyroid dysfunction. Materials and Methods: The study was designed as cross-sectional observational study and analysis of values was done by significant tests difference in means. 20 patients with hypothyroidism, 20 patients with hyperthyroidism, and 20 normal were participated in the study. Levels of total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), LDL-C, and LDL/HDL ratio were estimated and compared. Results: In patients with hypothyroidism, there was an increase in total cholesterol, LDL-C, and triglyceride levels and decrease in HDL-C levels. In hyperthyroidism, total cholesterol, triglycerides, LDL-C, VLDL-C, and LDL/HDL ratio were found to be significantly decreased. Conclusion: Altered thyroid function can lead to significant changes in the lipid profile. Hypothyroidism is an important risk factor for heart diseases. Hence, routine screening of thyroid hormones may be of considerable help for early intervention and treatment of thyroid dysfunction-related cardiac disease.
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Keywords
Thyroid Dysfunction, Hypothyroidism, Hyperthyroidism, Lipid Profile, Total Cholesterol, Triglycerides, High Density Lipoprotein-Cholesterol, Low Density Lipoprotein-Cholesterol, Very Low Density Lipoprotein Cholesterol, Low Density Lipoprotein/High Density Lipoprotein Ratio
Citation
D BP, Maliekkal J, N G, H ANV. . A study on lipid profile in thyroid dysfunction. National Journal of Physiology, Pharmacy and Pharmacology. 2023 Jun; 13(6): 1174-1178