The significance and technical aspects of quantitative measurements of inflammatory mediators in allergic rhinitis.

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dc.contributor.authorWang, D Yen_US
dc.contributor.authorYeoh, K Hen_US
dc.date.accessioned2009-05-27T17:24:39Z
dc.date.available2009-05-27T17:24:39Z
dc.date.issued1999-09-04en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand. 38 references.en_US
dc.description.abstractThe pathophysiology of allergic rhinitis induced by various inhalant allergens through an IgE mediated mechanism, has been well demonstrated. The participation of many important inflammatory cells and mediators released by these cells in the human nasal allergic reaction provides insight into the relationship between the responsiveness to allergen exposure and nasal symptoms of allergic rhinitis. This paper summarizes our previous studies on some important mediators in the nasal secretions of atopic patients during different phases after nasal allergen challenge and during natural allergen exposure. The microsuction technique proves to be an especially useful and reliable nasal sampling method permitting quantitative analysis of important mediators such as histamine, tryptase, leukotriene C4 and eosinophil cationic protein in nasal secretions. The measurement of these mediators during allergic reactions provides accurate data on the activity of some important inflammatory cells (i.e., mast cells, basophils, and eosinophils) and their responses to therapy.en_US
dc.description.affiliationDepartment of Otolaryngology, National University of Singapore, Singapore.en_US
dc.identifier.citationWang DY, Yeoh KH. The significance and technical aspects of quantitative measurements of inflammatory mediators in allergic rhinitis. Asian Pacific Journal of Allergy and Immunology. 1999 Sep; 17(3): 219-28en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37131
dc.language.isoengen_US
dc.subject.meshAllergens --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation Mediators --analysisen_US
dc.subject.meshNasal Mucosa --secretionen_US
dc.subject.meshRhinitis, Allergic, Perennial --immunologyen_US
dc.titleThe significance and technical aspects of quantitative measurements of inflammatory mediators in allergic rhinitis.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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