Clinical profile of Chikungunya in infants.

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dc.contributor.authorValamparampil, Joseph Jen_US
dc.contributor.authorChirakkarot, Shibien_US
dc.contributor.authorLetha, Sen_US
dc.contributor.authorJayakumar, Cen_US
dc.contributor.authorGopinathan, K Men_US
dc.date.accessioned2009-02-01en_US
dc.date.accessioned2009-05-30T13:21:43Z
dc.date.available2009-02-01en_US
dc.date.available2009-05-30T13:21:43Z
dc.date.issued2009-02-01en_US
dc.description.abstractOBJECTIVE: To define the clinical manifestations of Chikungunya infection in infants. METHODS: The inclusion criteria was fever (defined as axillary temperature > 99.6 degrees F) with any one of the following features; seizure, loose stools, peripheral cyanosis, skin manifestations or pedal edema in children less than one year. Details of disease from onset of illness till admission were noted and a thorough clinical examination was done at the time of admission. Daily follow-up was performed and the serial order of appearance of clinical features was noted till complete recovery. The sera collected from patients after the 7th day of onset of fever was analyzed for specific chikungunya antibody by IgM antibody capture enzyme linked immunosorbent assay (ELISA). RESULTS: Fifty six (56) infants were laboratory confirmed for chikungunya, consisting of 34 (60.71%) males and 22 (39.29%) females. 4 (7.14%) infants were less than 1 month of age, 39 (69.64%) 2-6 months old and 13 (23.21%) 7-12 months old. Fever was invariably present, but associated constitutional symptoms in infants consisted of lethargy or irritability and excessive cry. The most characteristic feature of the infection in infants was acrocyanosis and symmetrical superficial vesicobullous lesions were noted in most infants. Erythematous asymmetrical macules and patches were observed which later progressed to morbiliform rashes. The face and oral cavity was spared in all observed patients. CONCLUSION: An entirely different spectrum of disease is seen in infants with chikungunya as compared to older children who need to be carefully observed for. The morbidity and mortality of the disease may be avoided by the rational use of drugs and close monitoring of all infants.en_US
dc.description.affiliationDepartment of Pediatrics, Institute of Child Health, Government Medical College, Kerala, India.en_US
dc.identifier.citationValamparampil JJ, Chirakkarot S, Letha S, Jayakumar C, Gopinathan KM. Clinical profile of Chikungunya in infants. Indian Journal of Pediatrics. 2009 Feb; 76(2): 151-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/81611
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAlphavirus Infections --diagnosis
dc.subject.meshAlphavirus Infections --immunology
dc.subject.meshAlphavirus Infections --virology
dc.subject.meshChikungunya virus --isolation & purification
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoglobulin M
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshMale
dc.subject.meshSkin Diseases --diagnosis
dc.subject.meshSkin Diseases --immunology
dc.subject.meshSkin Diseases --virology
dc.titleClinical profile of Chikungunya in infants.en_US
dc.typeJournal Articleen_US
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