Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India.

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dc.contributor.authorMahajan, R C
dc.contributor.authorNarain, K
dc.contributor.authorMahanta, J
dc.date.accessioned2011-12-07T04:55:38Z
dc.date.available2011-12-07T04:55:38Z
dc.date.issued2011-06
dc.description.abstractBackground & objectives: Severe anaemia in Plasmodium falciparum (Pf) associated malaria is a leading cause of death despite low levels of parasitaemia. In an effort to understand the pathogenesis of anaemia we studied expression level of RBC complement regulatory proteins, CR1 (CD35), CD55 and CD59 with haemoglobin status in a group of malaria cases from Assam, Goa and Chennai, and in healthy controls. Methods: Flowcytometry was used to study expression of CR1, CD55 and CD59 in 50 Pf cases and 30 normal healthy volunteers. Giemsa stained thick and thin blood films were used for microscopic detection and identification of malarial parasites and parasite count. Results: No correlation was found between degree of expression of RBC surface receptors CR1, CD55 and CD59 with haemoglobin level. However, expression of CD55 was less in malaria cases than in healthy controls. Interpretation & conclusions: The present findings indicate that malaria infection changes the expression profile of complement regulatory protein CD55 irrespective of severity status of anaemia. Further studies are needed to explore the pathophysiology of anaemia in malaria cases in Assam where expression of RBC complement receptors appears to be low even in normal healthy population.en_US
dc.identifier.citationMahajan R C, Narain K, Mahanta J. Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India. Indian Journal of Medical Research. 2011 June; 133(6): 662-664.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135712
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135996/en_US
dc.subjectAnaemiaen_US
dc.subjectAssamen_US
dc.subjectCD55en_US
dc.subjectCD59en_US
dc.subjectCR1en_US
dc.subjectChennaien_US
dc.subjectflowcytometryen_US
dc.subjectGoaen_US
dc.subjectIndiaen_US
dc.subjectPlasmodium falciparumen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnemia --blood
dc.subject.meshAnemia --immunology
dc.subject.meshAnemia --microbiology
dc.subject.meshAntigens, CD55 --immunology
dc.subject.meshAntigens, CD59 --immunology
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshErythrocytes --immunology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshInfant
dc.subject.meshMalaria, Falciparum --blood
dc.subject.meshMalaria, Falciparum --immunology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshReceptors, Complement 3b --immunology
dc.subject.meshYoung Adult
dc.titleAnaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India.en_US
dc.typeArticleen_US
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