Comparative analysis of concurrent and sequential chemoradiation in locally advanced lung cancer: a single institution experience

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dc.contributor.authorSrivastava, Shellyen_US
dc.contributor.authorSaini, Surendra Kumaren_US
dc.contributor.authorAgarwal, S. K.en_US
dc.date.accessioned2020-11-18T10:00:14Z
dc.date.available2020-11-18T10:00:14Z
dc.date.issued2019-12
dc.description.abstractBackground: Outcome of various treatment regimen are dismal in non-small cell lung cancer. This analysis is done to find possible care in authors institutional set up and to see how these protocols have effect in Indian patients in term of toxicity.Methods: Medical records and data on patients who had been diagnosed with non-small cell lung cancer histologically or cytologically, and who had been treated with sequential chemoradiation and concurrent chemoradiation at the hospital from January 2007 to March 2015 was retrospectively reviewed and analyzed. Two groups of sequential chemoradiotherapy and concurrent chemoradiotherapy were formed and compared for outcomes.Results: Of the 114 evaluable patients in sequential chemoradiotherapy group, the median survival time was 16.0 months and the 1, 3- and 5-years overall survival were 57.0, 26.9 and 21.2%, respectively. Median progression free survival (PFS was 13.0 months and the 1, 3 and 5 years PFS were 52.6, 14.6 and 7.8%, respectively. In concurrent chemoradiotherapy group (105 patients), the overall median survival time was 15 months and the 1, 3- and 5-year overall survival were 56.2, 20.6 and 14.7%, respectively. Median PFS was 13 months and the 1, 3 and 5-year PFS were 48.8, 19.7 and 10.3%, respectively. Grade 3 and 4 toxicity in both regimen groups are same and statistically not significant.Conclusions: Analysis confirm dismal outcome with standard treatment and signifies to search for care beyond conventional chemoradiotherapy.en_US
dc.identifier.affiliationsDepartment of Radiotherapy, M. P. Shah Government Medical College, Jamnagar, Gujarat, Indiaen_US
dc.identifier.citationSrivastava Shelly, Saini Surendra Kumar, Agarwal S. K.. Comparative analysis of concurrent and sequential chemoradiation in locally advanced lung cancer: a single institution experience. International Journal of Research in Medical Sciences. 2019 Dec; 7(12): 4686-4690en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211942
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20195504en_US
dc.subjectConcurrent chemoradiotherapy, Lung cancer, Non-small cell lung cancer, Sequential chemoradiotherapyen_US
dc.titleComparative analysis of concurrent and sequential chemoradiation in locally advanced lung cancer: a single institution experienceen_US
dc.typeJournal Articleen_US
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