Effect of Oral Administration of Ibuprofen on Prothrombin Time, Activated Partial Thromboplastin and Platelet Count in Wistar Albino Rats

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dc.contributor.authorEsima, Jonathanen_US
dc.contributor.authorZorte, Abrahamen_US
dc.contributor.authorOnwuli, O.en_US
dc.contributor.authorDonatusen_US
dc.contributor.authorWariboen_US
dc.contributor.authorAnthony, Helenen_US
dc.date.accessioned2020-11-18T10:30:23Z
dc.date.available2020-11-18T10:30:23Z
dc.date.issued2020-05
dc.description.abstractAim:Ibuprofen is analgesic, antipyretic and anti-inflammatory drug, which is widely used as a cheap over-the counter drug(OTC); however, this drug accompanies anti coagulation/anti platelets effects which sometimes might illicit adverse effects. In this study, we investigated effect of ibuprofen on prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelet count using wistar albino rats.Methods:A total of 21 rats grouped into 3(control, acute and chronic exposure groups, with all consisting of 7rats each) was used. The acute and chronic exposure group were given 0.7mg of ibuprofen orally for 1 and 21 days, respectively. Blood sample was collected via cardiac puncture thenanalyzed.Results:PT was significantly higher in both group 2 and 3 (acute and chronic exposure, respectively)than that of the control. Acute exposure group showed the highest PT rise.A PTT was not significantly different between group 2 and 3 versus the control group. Platelet count was significantly lower in both group 2 and 3than that in the control group (p<0.05). Group 3 (chronic exposure) showed the lowest platelet count.Conclusion:Oral administration of ibuprofen affected coagulation parameters and a longer exposure reduce platelets count. A strictly prescription for this drug may be needed to prevent its indiscriminate useen_US
dc.identifier.affiliationsDepartment of Medical Laboratory Science, Faculty of Science, Rivers State University, P.M.B.5080, NkpoluOroworukwo, Port Harcourt, Nigeriaen_US
dc.identifier.citationEsima Jonathan, Zorte Abraham, Onwuli O., Donatus, Waribo, Anthony Helen. Effect of Oral Administration of Ibuprofen on Prothrombin Time, Activated Partial Thromboplastin and Platelet Count in Wistar Albino Rats. Journal of Pharmaceutical Research International. 2020 May; 32(6): 45-50en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215940
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber6en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i630445en_US
dc.subjectIbuprofenen_US
dc.subjectprothrombin time (PT)en_US
dc.subjectactivated partial thromboplastin time (aPTT)en_US
dc.subjectplatelet counten_US
dc.subjectwistar albino ratsen_US
dc.titleEffect of Oral Administration of Ibuprofen on Prothrombin Time, Activated Partial Thromboplastin and Platelet Count in Wistar Albino Ratsen_US
dc.typeJournal Articleen_US
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