Irreversible electroporation and adjuvant chemoradiotherapy for locally advanced pancreatic carcinoma

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dc.contributor.authorXu, Kaien_US
dc.contributor.authorChen, Yongliangen_US
dc.contributor.authorSu, Junjunen_US
dc.contributor.authorSu, Mingen_US
dc.contributor.authorLi, Yanen_US
dc.date.accessioned2020-11-18T10:08:18Z
dc.date.available2020-11-18T10:08:18Z
dc.date.issued2020-05
dc.description.abstractContext: The safety and efficacy of irreversible electroporation (IRE) for locally advanced pancreatic carcinoma (LAPC) are well established. However, whether adjuvant chemoradiotherapy after IRE increases, the survival rate remains unknown. Therefore, this study evaluated the effect of chemoradiotherapy combined with IRE in patients with LAPC. Subjects and Methods: We retrospectively analyzed 42 patients with LAPC between July 2015 and December 2016 at PLA General Hospital treated with IRE or IRE combined with radiation and/or chemotherapy. These patients were divided into the IRE group and the combined-therapy group. All patients underwent computed tomography (CT), magnetic resonance imaging, and positron-emission tomography-CT and no signs of metastases were found. The prognosis of these patients was observed. Results: The times after operation and after diagnosis in the combined-therapy group (304.20 ± 118.54) and (334.40 ± 114.07) days, respectively, were better those than in the IRE group (214.36 ± 95.68) and (244.68 ± 110.61) days, respectively. Moreover, patients in the combined-therapy group had a significantly better survival rate than the IRE group (80 vs. 45.45%, P < 0.05). Conclusions: IRE combined with radiotherapy or chemotherapy was superior to IRE alone for the treatment of LAPC, as it prolonged the survival time and improved the survival rate, making it worthy of wide dissemination and clinical applicationen_US
dc.identifier.affiliationsDepartment of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, Chinaen_US
dc.identifier.affiliationsDepartment of Gastro-Pancreatic Surgery, Shanxi Provincial People's Hospital, Taiyuan, Chinaen_US
dc.identifier.affiliationsDepartment of General Surgery, The 89th Hospital of the People's Liberation Army of China, Beijing, Chinaen_US
dc.identifier.citationXu Kai, Chen Yongliang, Su Junjun, Su Ming, Li Yan. Irreversible electroporation and adjuvant chemoradiotherapy for locally advanced pancreatic carcinoma. Journal of Cancer Research and Therapeutics. 2020 May; 16(2): 280-285en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213814
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_773_18en_US
dc.subjectChemotherapyen_US
dc.subjectirreversible electroporationen_US
dc.subjectpancreatic carcinomaen_US
dc.subjectradiotherapyen_US
dc.titleIrreversible electroporation and adjuvant chemoradiotherapy for locally advanced pancreatic carcinomaen_US
dc.typeJournal Articleen_US
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