Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity.

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dc.contributor.authorChanta, Chulapongen_US
dc.contributor.authorTriratanapa, Krilerken_US
dc.contributor.authorRatanasirichup, Preechaen_US
dc.contributor.authorMahaprom, Warangkanaen_US
dc.date.accessioned2009-05-27T18:20:55Z
dc.date.available2009-05-27T18:20:55Z
dc.date.issued2007-11-10en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: Determine the frequency of abnormalities of liver function test in children with scrub typhus and its relation with severity of disease. MATERIAL AND METHOD: Fifty-four children diagnosed with scrub typhus at Chiang Rai Regional Hospitalfrom January 2004 to December 2005 were studied. The diagnosis of scrub typhus in the present study was based on a single indirect immunofluorescent antibody (IFA) titer against O tsutsugamushi of > or = 1:400 or a four fold or greater rise in IFA titer to at least 1:200. Liver function tests (LFT) were done on the first few days of admission in all patients. Abnormalities of LFT were focused on serum AST, ALT albumin and total bilirubin level. All of the patients were divided into two groups based on the presence or absence of complications. RESULTS: Fifty-two patients (96.3%) had abnormal LFT. Evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were detected in 52 (96.3%) and 36 (66.7%) cases, respectively. Hypoalbuminemia and hyperbilirubinemia were detected in 23 (42.6%) and 4 (7.4%) cases, respectively. The higher level of AST, ALT and lower level ofserum albumin correlated significantly with the severity of scrub typhus in children. CONCLUSION: Hepatic dysfunction is common in children with scrub typhus. Elevation of AST level may be used as a screening test for diagnosis of scrub typhus in areas where rapid diagnostic test is not commercially available. Increased AST, ALT and hypoalbuminemia related with severity of disease.en_US
dc.description.affiliationPediatric Unit, Chiang Rai Regional Hospital, Chiang Rai, Thailand.en_US
dc.identifier.citationChanta C, Triratanapa K, Ratanasirichup P, Mahaprom W. Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. Journal of the Medical Association of Thailand. 2007 Nov; 90(11): 2366-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38965
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAlanine Transaminaseen_US
dc.subject.meshAspartate Aminotransferasesen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshChilden_US
dc.subject.meshChild Welfareen_US
dc.subject.meshFemaleen_US
dc.subject.meshHealth Status Indicatorsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Diseases --diagnosisen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshScrub Typhus --complicationsen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSickness Impact Profileen_US
dc.subject.meshTime Factorsen_US
dc.titleHepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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