Clinical spectrum, susceptibility profile, treatment and outcome of culture-confirmed brucellosis from South India

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dc.contributor.authorMani, SSen_US
dc.contributor.authorGunasekaran, Ken_US
dc.contributor.authorIyyadurai, Ren_US
dc.contributor.authorPrakash, JAen_US
dc.contributor.authorVeeraraghavan, Ben_US
dc.contributor.authorMishra, AKen_US
dc.contributor.authorSabnis, Ken_US
dc.contributor.authorVictor, PJen_US
dc.contributor.authorMartin, Sen_US
dc.contributor.authorChandiraseharan, VKen_US
dc.contributor.authorHansdak, SGen_US
dc.contributor.authorVarghese, GMen_US
dc.date.accessioned2020-04-23T07:36:20Z
dc.date.available2020-04-23T07:36:20Z
dc.date.issued2018-06
dc.description.abstractBrucellosis, a common zoonosis, is under reported in India despite its endemicity and increased exposure to livestock among the population. This study was conducted to determine the clinical manifestations, antibiotic susceptibility pattern, treatment and outcome of culture confirmed brucellosis. Adult patients with culture confirmed brucellosis who presented to a large teaching hospital in South India between 2009 and 2015 were included. A diagnosis of brucellosis was confirmed on automated culture. Clinical profile, laboratory parameters, drug susceptibility, treatment and outcome were documented by reviewing the medical records. The cohort comprised of 22 patients with mean ± SD age of 42 ± 13 years. Twenty one (95.5%) was male. Thirteen (59%) patients were from rural area and risk of acquisition of brucellosis including occupational exposure or consumption of unpasteurized milk was evident in 16 (72.7%) patients. The mean duration of symptoms before presentation was 54.5 ± 52 days. The commonest clinical presentation was prolonged fever without a definite focus in 18 patients (82%), whereas 2 (9%) patients had osteoarticular involvement and one patient (4.5%) each had genital involvement and endocarditis. Eighteen patients (82%) with uncomplicated brucellosis were treated with aminoglycoside and doxycycline for 6 weeks. There was no relapse or mortality at 18 ± 9 months of follow up. Brucellosis in this cohort had acute or subacute presentation with prolonged fever and bacteremia. High index of clinical suspicion based on significant epidemiological history along with automated blood culture improves the efficiency of diagnosis. Cure with lack of relapse among these cases suggests a combination therapy with doxycycline and aminoglycoside is highly effective for the treatment.en_US
dc.identifier.affiliationsDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.citationMani SS, Gunasekaran K, Iyyadurai R, Prakash JA, Veeraraghavan B, Mishra AK, Sabnis K, Victor PJ, Martin S, Chandiraseharan VK, Hansdak SG, Varghese GM. Clinical spectrum, susceptibility profile, treatment and outcome of culture-confirmed brucellosis from South India. Indian Journal of Medical Microbiology. 2018 Jun; 36(2): 289-292en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198771
dc.languageenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.issuenumber2en_US
dc.relation.volume36en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmm.IJMM_18_236en_US
dc.subjectBrucellosisen_US
dc.subjectcultureen_US
dc.subjectSouth Indiaen_US
dc.subjectzoonosisen_US
dc.titleClinical spectrum, susceptibility profile, treatment and outcome of culture-confirmed brucellosis from South Indiaen_US
dc.typeJournal Articleen_US
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