Peroxynitrite: a potent oxidizing and nitrating agent.

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dc.contributor.authorKamat, J Pen_US
dc.date.accessioned2009-05-28T14:41:06Z
dc.date.available2009-05-28T14:41:06Z
dc.date.issued2006-06-21en_US
dc.description114 references.en_US
dc.description.abstractNitric oxide (NO*) reacts with superoxide (O2-*) forming peroxynitrite (PXN) (ONOO-), a strong oxidant which reacts with several biomolecules leading to enormous implications in biological process, holds enormous implications for the understanding of free radicals. The ONOO- formation in vivo has significant implications in free radical biology. It exerts a defensive role in large number of pathophysiological reactions and also acts as signaling molecule in activation of several protooncogenes. It decomposes rapidly to an intermediate and reacts with several biomolecules. Evidence for PXN formation in vivo has been obtained immunohistochemically through detection of a characteristic reaction product with protein tyrosine residues and 3-nitrotyrosine. This "biomarker" of PXN formation has now been identified in various pathologies such as Lou Gehrig's disease, Parkinson's disease, cancer, atherosclerosis as well as in biological aging. 3-nitrotyrosine formation has been documented in various tissues, e.g. even in non-diseased embryonic heart during normal development. Therefore, there is a great opportunity in the postgenomic period to understand the interplay of these molecular interactions with biological events such as apoptosis, gene regulation etc. This review deals with biological significance of peroxynitrite, its precursors, reactions with large range of biomolecules, including aminoacids, proteins, lipids, nucleic acids, antioxidants as well as cytotoxic aspects.en_US
dc.description.affiliationRadiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India. jkamat@magnum.barc.ernet.inen_US
dc.identifier.citationKamat JP. Peroxynitrite: a potent oxidizing and nitrating agent. Indian Journal of Experimental Biology. 2006 Jun; 44(6): 436-47en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61027
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6520/1/IJEB%2044%286%29%20436-447.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshFree Radicals --chemistryen_US
dc.subject.meshGlutathione Peroxidase --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshNitric Oxide --chemistryen_US
dc.subject.meshNitrogen --chemistryen_US
dc.subject.meshOxidants --chemistryen_US
dc.subject.meshOxygen --metabolismen_US
dc.subject.meshPeroxynitrous Acid --chemistryen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.titlePeroxynitrite: a potent oxidizing and nitrating agent.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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