The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice

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dc.contributor.authorMohammadi, Shabnamen_US
dc.contributor.authorBeheshti, Farimahen_US
dc.contributor.authorElyasi, Sepidehen_US
dc.contributor.authorJalali, Mehdien_US
dc.date.accessioned2020-11-18T10:30:16Z
dc.date.available2020-11-18T10:30:16Z
dc.date.issued2020-08
dc.description.abstractThe aim of this study was to investigate the effects of propranolol on sperms, histopathology of testes, andCatSper 2 gene and protein expression in adult mice.18 adult male mice were randomly divided into control, propranolol 1 (receiving 10 mg/kg dose) and propranolol 2 group (receiving 15 mg/kg dose for 35 days). The mean amount of sperm parameters in the propranolol 1 and propranolol 2 groups was significantly lower than the control group (p<0.05). CatSper2 gene and protein expression have significantly decreased in propranolol 1 and propranolol 2 groups compared to the control group (P<0.05). Reduction of CatSper2 gene and protein expression in low dose of propranolol was more severe than high dose. In testicular tissues of the propranolol 1 group, vacuoles and necrosis in the germinal epithelium were observed, and in testicular tissues of propranolol 2 group decrease in the thickness of the germinal epithelium, some vacuoles and necrosis were observed in germinal epithelium as well as congestion in the interstitial space. The mean value of thiol and catalase enzyme in the propranolol 1 and propranolol 2 groups, and the mean value of superoxide dismutase in propranolol 1 group, were significantly different compared to the control group (P<0.05)en_US
dc.identifier.affiliationsDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.identifier.affiliationsNeuroscience Research Center,TorbatHeydariyehUniversity of Medical Sciences,TorbatHeydariyeh, Iranen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.identifier.affiliationsDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.identifier.citationMohammadi Shabnam, Beheshti Farimah, Elyasi Sepideh, Jalali Mehdi. The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice. Journal of Pharmaceutical Research International. 2020 Aug; 32(14): 54-63en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215852
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber14en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i1430606en_US
dc.subjectCatSperen_US
dc.subjectmiceen_US
dc.subjectspermen_US
dc.subjecttestisen_US
dc.subjectgeneen_US
dc.subjectproteinen_US
dc.subjectpropranololen_US
dc.titleThe Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Miceen_US
dc.typeJournal Articleen_US
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