Human malaria in C57BL/6J mice: An in vivo model for chemotherapy studies.

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dc.contributor.authorSunita, K
dc.contributor.authorRajyalakshmi, M
dc.contributor.authorKumar, K Kalyan
dc.contributor.authorSowjanya, M
dc.contributor.authorSatish, P V V
dc.contributor.authorPrasad, D Madhu
dc.date.accessioned2014-04-29T09:56:29Z
dc.date.available2014-04-29T09:56:29Z
dc.date.issued2014-01
dc.description.abstractThe present work deals with the development of Plasmodium falciparum stages in mouse model and its potential for the study of efficacy of antimalarial drugs. C57BL/6J mice were infected with multidrug resistant P. falciparum strain then treated with arteether and artesunate. A response was observed to antimalarial drugs in terms of decrease in parasitemia. Mice infected with P. falciparum strain were successfully cured after treatment with either arteether or artesunate. The speed of parasite clearance time and burden of parasitemia differed for each drug and matched the previously reported observations, hence stressing the relevance of the model. These findings thus suggest that P. falciparum. infected human RBC (iRBC) – C57BL/6J mice can provide a valuable in vivo system and should be included in the short list of animals that can be used for the evaluation of P. falciparum responses to drugs.en_US
dc.identifier.citationSunita K, Rajyalakshmi M, Kumar K Kalyan, Sowjanya M, Satish P V V, Prasad D Madhu. Human malaria in C57BL/6J mice: An in vivo model for chemotherapy studies. Indian Journal of Experimental Biology. 2014 Jan; 52(1): 67-72.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150334
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/25152en_US
dc.subjectArteetheren_US
dc.subjectArtesunateen_US
dc.subjectParasitemiaen_US
dc.subjectPlasmodium falciparumen_US
dc.subject.meshAnimals
dc.subject.meshArtemisinins --administration & dosage
dc.subject.meshDisease Models, Animal
dc.subject.meshDrug Resistance, Multiple --genetics
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMalaria --drug therapy
dc.subject.meshMalaria --metabolism
dc.subject.meshMalaria --parasitology
dc.subject.meshMice
dc.subject.meshMice, Inbred C57BL
dc.subject.meshParasitemia --drug therapy
dc.subject.meshPlasmodium falciparum --growth & development
dc.subject.meshPlasmodium falciparum --pathogenicity
dc.titleHuman malaria in C57BL/6J mice: An in vivo model for chemotherapy studies.en_US
dc.typeArticleen_US
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