Morphological spectrum of leukemic mantle cell lymphoma.

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dc.contributor.authorRahman, Khaliqur
dc.contributor.authorSubramanian, P G
dc.contributor.authorKadam, Pratibha Amare
dc.contributor.authorGadage, Vijaya
dc.contributor.authorGalani, Komal
dc.contributor.authorMittal, Neha
dc.contributor.authorGhogale, Sitaram
dc.contributor.authorBadrinath, Yajamanam
dc.contributor.authorAnsari, Rashida
dc.contributor.authorKushte, Shilpa
dc.contributor.authorNair, Reena
dc.contributor.authorSengar, Manju
dc.contributor.authorMenon, Hari
dc.contributor.authorGujral, Sumeet
dc.date.accessioned2012-10-16T05:07:50Z
dc.date.available2012-10-16T05:07:50Z
dc.date.issued2012-01
dc.description.abstractBackground: Leukemic involvement in mantle cell lymphoma (MCL) is common, and can be secondary to nodal or extranodal disease or can be de-novo. There is paucity of literature that describes the morphological spectrum. Aim: This study was aimed at studying the morphological spectrum of leukemic MCL and to correlate the morphology with other features. Materials and Methods: Twenty six such cases diagnosed over a period of four years were studied. Peripheral blood and bone marrow aspiration smears stained with Wrights stain were examined by three hematopathologists. Immunophenotyping was done using multicolor flow cytometry. Fluorescence in situ hybridization (FISH) done in 12 cases showed t(11;14)(q13:q32). Results: Six cases had de-novo leukemic involvement; while 20 cases had secondary involvement. Morphologically, the cells were small (less than twice the size of red blood cell) or large. Small cell morphology in turn showed irregular nuclear border (n=13) or round nuclear contour (n=6). Large cells had blastic morphology (n=5) or had central prominent nucleoli resembling prolymhphocytes (n=2). Twenty cases showed characteristic immunophenotype of CD5+/CD19+/CD20+/FMC7+/CD10-/CD23- and light chain restrictions. Three cases expressed CD23 and two cases were negative for FMC7. Five out of 12 cases, where FISH was done, showed cytogenetic abnormalities in addition to t(11;14)(q13;q32). Conclusion: Morphological spectrum of leukemic MCL ranges from small cells resembling chronic lymphocytic leukemia (CLL) or follicular lymphoma (FL) to large cell mimicking prolymphocytic leukemia (PLL) or acute leukemia. Large cell morphology was associated with more frequent additional cytogenetic abnormality as well as a poorer outcome.en_US
dc.identifier.citationRahman Khaliqur, Subramanian P G, Kadam Pratibha Amare, Gadage Vijaya, Galani Komal, Mittal Neha, Ghogale Sitaram, Badrinath Yajamanam, Ansari Rashida, Kushte Shilpa, Nair Reena, Sengar Manju, Menon Hari, Gujral Sumeet. Morphological spectrum of leukemic mantle cell lymphoma. Indian Journal of Pathology & Microbiology. 2012 Jan-Mar 55(1): 66-71.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142179
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=1;spage=66;epage=71;aulast=Rahmanen_US
dc.subjectDe novo leukemic involvementen_US
dc.subjectmantle cell lymphomaen_US
dc.subjectmorphological spectrumen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBlood Cells --cytology
dc.subject.meshBone Marrow --pathology
dc.subject.meshFemale
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshLymphoma, Mantle-Cell --pathology
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.titleMorphological spectrum of leukemic mantle cell lymphoma.en_US
dc.typeArticleen_US
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