Survey of human papillomavirus infection in cervical intraepithelial neoplasia in Thai women.

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dc.contributor.authorBhattarakosol, Parvapanen_US
dc.contributor.authorLertworapreecha, Monthonen_US
dc.contributor.authorKitkumthorn, Nakarinen_US
dc.contributor.authorTriratanachai, Surangen_US
dc.contributor.authorNiruthisard, Somchaien_US
dc.date.accessioned2009-05-27T18:58:54Z
dc.date.available2009-05-27T18:58:54Z
dc.date.issued2002-06-22en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractHPV infection is known to be associated with cervical cancer development. Precancerous lesions named cervical intraepithelial neoplasia (CIN) are divided into 3 grades, i.e., CIN-1, CIN-2, and CIN-3. Here, HPV infection determined by PCR and dot hybridization was observed in these 3 different grades of formalin-fixed paraffin embedded tissues. The HPV infection was demonstrated in 33.3 per cent of CIN-1, 36.8 per cent of CIN-2 and 75 per cent of CIN-3. Using type specific probes for HPV-6, 11, 16, 18 and 33, HPV-16 was the most prevalent type (44.44%) followed by HPV-18 (16.05%) in CIN-3. Only one HPV-18 was identified in CIN-1 while CIN-2 contained one HPV-6 and one HPV-18. Mixed infection was found in CIN-3 (12.35%). All of them had HPV-16. The cervicitis cases with normal histopathology were included as control. Only 2.7 per cent of HPV infection was shown. The relative risk of HPV infection was high in CIN-3 (OR = 107.25, 95% CI = 50.29-228.73). Our data confirm the association between high-risk HPV types and development of CIN.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Medicine, Chulalongkom University, Bangkok, Thailand.en_US
dc.identifier.citationBhattarakosol P, Lertworapreecha M, Kitkumthorn N, Triratanachai S, Niruthisard S. Survey of human papillomavirus infection in cervical intraepithelial neoplasia in Thai women. Journal of the Medical Association of Thailand. 2002 Jun; 85 Suppl 1(): S360-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40235
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCervical Intraepithelial Neoplasia --epidemiologyen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshData Collectionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPapillomaviridae --isolation & purificationen_US
dc.subject.meshPapillomavirus Infections --epidemiologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrecancerous Conditions --pathologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTumor Virus Infections --epidemiologyen_US
dc.subject.meshUterine Cervical Neoplasms --epidemiologyen_US
dc.titleSurvey of human papillomavirus infection in cervical intraepithelial neoplasia in Thai women.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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