Chromosome analysis of uncultured amniocytes by comparative genomic hybridization in early amniocentesis.

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dc.contributor.authorKetupanya, Aphornpiromen_US
dc.contributor.authorAranyakasemsuk, Niwaten_US
dc.contributor.authorTocharoentanaphol, Chintanaen_US
dc.contributor.authorVuthiwong, Chutawadien_US
dc.date.accessioned2009-05-27T18:37:44Z
dc.date.available2009-05-27T18:37:44Z
dc.date.issued2005-11-25en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To study chromosome analysis by comparative genomic hybridization (CGH) compared with the conventional technique in early amniocentesis. MATERIAL AND METHOD: Cross-sectional descriptive study design was performed in 32 singleton pregnant women with gestational age between 12-15 weeks. Transabdominal amniocentesis was carried out under ultrasound guidance. The amniotic fluid samples were simultaneously investigated using CGH and the conventional cytogenetics study as a gold standard. RESULTS: Amniocentesis were done for advanced maternal age in all cases. The mean maternal age was 35.8 years (35-42 years). The mean gestational age was 13.7 weeks (12-15 weeks). The chromosome analysis by CGH technique of uncultured amniocyte showed 17 normal female chromosomes (53.1%) and 15 normal male chromosomes (46.9%). This finding was the same as the conventional cytogenetics method. The mean duration of the CGH method was 6 days and that of the conventional cytogenetics method was 13.7 days (10-23 days). CONCLUSION: The CGH technique is a reliable technique for a rapid prenatal diagnosis of chromosome study in early gestation.en_US
dc.description.affiliationDepartment of Obstetrics, Phramongkutklao Hospital, Bangkok, Thailand. chrodna@yahoo.comen_US
dc.identifier.citationKetupanya A, Aranyakasemsuk N, Tocharoentanaphol C, Vuthiwong C. Chromosome analysis of uncultured amniocytes by comparative genomic hybridization in early amniocentesis. Journal of the Medical Association of Thailand. 2005 Nov; 88 Suppl 3(): S1-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39531
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshAmniotic Fluid --cytologyen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotyping --methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPregnancyen_US
dc.subject.meshReproducibility of Resultsen_US
dc.titleChromosome analysis of uncultured amniocytes by comparative genomic hybridization in early amniocentesis.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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