Extraovarian endocrine abnormalities in north Indian women with premature ovarian failure.

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dc.contributor.authorShah, Aen_US
dc.contributor.authorMithal, Aen_US
dc.contributor.authorBhatia, Een_US
dc.contributor.authorGodbole, M Men_US
dc.date.accessioned1995-01-01en_US
dc.date.accessioned2009-06-03T06:23:13Z
dc.date.available1995-01-01en_US
dc.date.available2009-06-03T06:23:13Z
dc.date.issued1995-01-01en_US
dc.description.abstractBACKGROUND. Premature ovarian failure is a rare syndrome characterized by cessation of menstruation before 35 years of age associated with an elevated gonadotropin level (serum follicle stimulating hormone > 40 IU/L) and oestrogen deficiency. Premature ovarian failure is often the result of an autoimmune process and involvement of other endocrine glands has been reported but available studies are hampered by a lack of uniformity in diagnostic criteria. METHODS. The endocrine profile of 37 north Indian women with premature ovarian failure was studied. The investigations included measurement of serum follicle stimulating hormone, luteinizing hormone, oestradiol, prolactin, total thyroxine, total triiodothyronine and thyroid stimulating hormone. To assess adrenocortical reserve, adrenocorticotropic hormone stimulated plasma cortisol levels were estimated. RESULTS. Eighteen (49%) patients had extraovarian endocrine abnormalities. Eight (22%) had abnormal thyroid function tests and 12 of 29 (41%) patients tested for adrenocortical reserve showed impaired response of plasma cortisol to adrenocorticotropic hormone stimulation. CONCLUSION. Extraovarian endocrine (especially adrenocortical) involvement is frequent in patients with premature ovarian failure. Because none of the patients had overt clinical evidence of thyroid or adrenocortical disease, we suggest that tests for thyroid and adrenal function be performed routinely in females presenting with premature ovarian failure.en_US
dc.description.affiliationCentre for Endocrine Sciences, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.en_US
dc.identifier.citationShah A, Mithal A, Bhatia E, Godbole MM. Extraovarian endocrine abnormalities in north Indian women with premature ovarian failure. National Medical Journal of India. 1995 Jan-Feb; 8(1): 9-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119009
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenal Cortex Function Testsen_US
dc.subject.meshAdrenal Glands --abnormalitiesen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshGonadotropins, Pituitary --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshOvarian Failure, Premature --blooden_US
dc.subject.meshThyroid Function Testsen_US
dc.titleExtraovarian endocrine abnormalities in north Indian women with premature ovarian failure.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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