A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis.

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dc.contributor.authorSomani, V Ken_US
dc.date.accessioned2009-05-28T08:49:03Z
dc.date.available2009-05-28T08:49:03Z
dc.date.issued2008-03-05en_US
dc.description.abstractBACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, pruritic dermatitis frequently associated with the hyperproduction of IgE to various allergens. Identification of these allergens is possible by various laboratory investigations. AIM: The present study was designed to assess these allergen-specific antibodies in the diagnosis of AD in the Indian context. METHODS: This prospective study comprised 50 patients of AD. The diagnosis was made clinically after satisfying Hanifin and Rajka's criteria. Serum IgE levels were estimated and specific IgE antibodies were measured for 20 food allergens and aeroallergens. RESULTS: Serum IgE was elevated in 88% of the patients. The highest elevation of mean IgE levels was seen in the 10-20 years age group. Sixty five percent of the children under the age of ten years were positive to one or more food allergens. Food allergens were more often positive in the < or = 10 years age group and specific antibodies to inhalants were seen more frequently in the older age groups. Specific antibodies to apples were found in all age groups. CONCLUSION: Antibodies against apples and hazelnuts were the more commonly seen specific antibodies in children. Incidence of positivity was much higher in children when compared to earlier studies. Identification of food allergens can be an important factor in the diagnosis of AD in children in India. Positivity to inhalant allergens in the older age groups was lower in this study. The allergen profile with regard to inhalants in Indian patients was similar to that of earlier studies.en_US
dc.description.affiliationSomani Skin and Cosmetology Institute, Hyderabad, India. vksomani@rediffmail.comen_US
dc.identifier.citationSomani VK. A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis. Indian Journal of Dermatology, Venereology and Leprology. 2008 Mar-Apr; 74(2): 100-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53167
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAllergens --immunologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDermatitis, Atopic --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFood Hypersensitivity --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin E --biosynthesisen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.titleA study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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