L-carnitine in children with idiopathic dilated cardiomyopathy.

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dc.contributor.authorKothari, S Sen_US
dc.contributor.authorSharma, Men_US
dc.date.accessioned1998-01-16en_US
dc.date.accessioned2009-05-27T04:21:12Z
dc.date.available1998-01-16en_US
dc.date.available2009-05-27T04:21:12Z
dc.date.issued1998-01-16en_US
dc.description.abstractL-carnitine has been used in dilated cardiomyopathy secondary to carnitine deficiency in children, with favourable results. There are no reports on the effects of L-carnitine in children with idiopathic dilated cardiomyopathy. We undertook a prospective study to evaluate the effects of L-carnitine in children with idiopathic dilated cardiomyopathy. Thirteen children, mean age 3.29 +/- 1.44 years, with idiopathic dilated cardiomyopathy underwent echocardiographic evaluation while on conventional treatment alone, and with additional L-carnitine (50 mg/kg/day). To obviate the effects of spontaneous improvement, eight patients (Group 1) were restudied three weeks after stopping the drug, and five (Group 2) were restudied three weeks after addition of carnitine. Conventional treatment was continued throughout. After repeat echocardiographic examination, the parameters were compared statistically. With addition of carnitine, besides symptomatic improvement, the mean left ventricular ejection fraction improved from 36.9 +/- 16.1 percent to 46.9 +/- 14.5 percent (p < 0.001) and the mean pre-ejection period/left ventricular ejection time ratio from 39.07 +/- 14.8 to 43.2 +/- 8.1 (p < 0.01) in the entire group. These changes were concordant in both the subgroups. It was concluded that L-carnitine therapy in children with idiopathic dilated cardiomyopathy led to modest improvement in left ventricular function.en_US
dc.description.affiliationDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationKothari SS, Sharma M. L-carnitine in children with idiopathic dilated cardiomyopathy. Indian Heart Journal. 1998 Jan-Feb; 50(1): 59-61en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3957
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshCardiomyopathy, Dilated --drug therapyen_US
dc.subject.meshCarnitine --administration & dosageen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshStroke Volume --drug effectsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVentricular Function, Left --drug effectsen_US
dc.titleL-carnitine in children with idiopathic dilated cardiomyopathy.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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