Cancer related thrombophilia: clinical importance and management strategies.

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dc.contributor.authorGupta, P Ken_US
dc.contributor.authorCharan, V Den_US
dc.contributor.authorKumar, Hen_US
dc.date.accessioned2005-10-08en_US
dc.date.accessioned2009-05-30T18:12:15Z
dc.date.available2005-10-08en_US
dc.date.available2009-05-30T18:12:15Z
dc.date.issued2005-10-08en_US
dc.description44 references.en_US
dc.description.abstractAcquired thrombophilic state associated with a significant risk of thrombosis is frequently encountered in malignancy. Venous and arterial thromboembolism is a common complication and patients with cancer, also present with a hypercoagulable state, even in the absence of thrombosis. Furthermore, clotting activation may play a role in tumor progression. The pathogenesis of thrombosis in cancer is multifactorial; however, a relevant role is attributed to the tumor cell capacity to interact with and activate the host hemostatic system. Among other factors, the prothrombotic action of antitumor therapies is also important. Thrombotic events can influence the morbidity and mortality of the underlying disease. Therefore, preventing these complications in cancer patients is a clinically relevant issue. Recently, new approaches to the prevention and cure of thrombosis in cancer have been investigated, and the hypothesis that the strategies to inhibit clotting mechanism may favorably affect malignant disease is gaining increasing interest. In this article the various aspects of the complex relationship between thrombosis and cancer, from pathophysiology to therapy, are reviewed.en_US
dc.description.affiliationDepartment of Transfusion-Medicine, Armed Forces Medical College, Pune-411 040.en_US
dc.identifier.citationGupta PK, Charan VD, Kumar H. Cancer related thrombophilia: clinical importance and management strategies. Journal of the Association of Physicians of India. 2005 Oct; 53(): 877-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/85616
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAnticoagulants --therapeutic useen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasms --complicationsen_US
dc.subject.meshPulmonary Embolism --etiologyen_US
dc.subject.meshThrombophilia --etiologyen_US
dc.subject.meshVenous Thrombosis --etiologyen_US
dc.titleCancer related thrombophilia: clinical importance and management strategies.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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