Role of serum CA 19-9 as a tumor marker in TCC bladder

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dc.contributor.authorP., Rajeev T.en_US
dc.contributor.authorDas, Nabajeeten_US
dc.contributor.authorBaruah, S. J.en_US
dc.contributor.authorBarua, S. K.en_US
dc.contributor.authorBagchi, P. K.en_US
dc.contributor.authorSarma, D.en_US
dc.contributor.authorPhukan, M.en_US
dc.date.accessioned2020-11-18T09:57:54Z
dc.date.available2020-11-18T09:57:54Z
dc.date.issued2019-04
dc.description.abstractBackground: There is a dearth of reliable blood and urine markers for transitional cell carcinoma of urinary bladder. CA 19-9 is a well-known marker for gastrointestinal malignancies and is being investigated for other malignancies including carcinoma bladder. In this prospective study, we evaluated the role of serum CA 19-9 as a tumor marker and correlated its level with tumor grade and stage.Methods: One hundred and fifteen patients with transitional cell carcinoma of urinary bladder and 69 healthy volunteers, as controls were included in the study. Preoperative blood sample was analysed for level of CA 19-9 using ELISA kit (normal - 0 U/ml to 37U/ml) and were correlated with grade and TNM stage of tumor.Results: The range of the control group is 2-38U/ml (mean: 17.67±9.68U/ml); TCC group is 1-94U/ml (mean: 37.12±31.52U/ml) (p=0.304). When CA 19-9 level >37IU/ml was taken as cut-off for a positive test, sensitivity of detecting T3 disease, T4 disease, MIBC, presence of node and high grade tumour were 80%, 75%, 70.3%, 78% and 57.8% respectively. However, there was a statistically significant increase in levels of CA19-9 in relation to higher grade (<0.001), presence of muscle invasion (<0.001), T stage (<0.001) and N stage (<0.001).Conclusions: Serum CA19-9 is almost invariably raised in patients with high grade and invasive disease. Thus, it has a place as a prognostic marker rather than as a diagnostic tool due to its low sensitivity for TCC bladder.en_US
dc.identifier.affiliationsDepartment of Urology and Renal Transplantation, Gauhati Medical College Hospital, Guwahati, Assam, Indiaen_US
dc.identifier.citationP. Rajeev T., Das Nabajeet, Baruah S. J., Barua S. K., Bagchi P. K., Sarma D., Phukan M.. Role of serum CA 19-9 as a tumor marker in TCC bladder. International Journal of Research in Medical Sciences. 2019 Apr; 7(4): 1239-1246en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211174
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20191332en_US
dc.subjectHigh grade bladder canceren_US
dc.subjectMuscle invasive bladder canceren_US
dc.subjectPrognostic tumour markeren_US
dc.subjectTransitional cell carcinomaen_US
dc.subjectSerum tumor markeren_US
dc.subjectSerum CA 19-9en_US
dc.titleRole of serum CA 19-9 as a tumor marker in TCC bladderen_US
dc.typeJournal Articleen_US
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