Efficacy of Albendazole and Short-Course Prednisolone Treatment in Children with One or Two Ring-Enhancing Lesions of Neurocysticercosis: A Randomized Controlled Trial.
| dc.contributor.author | Swain, P K | |
| dc.contributor.author | Thapalial, A | |
| dc.contributor.author | Das, R N | |
| dc.contributor.author | Dhaliwal, M S | |
| dc.contributor.author | Subedi, K | |
| dc.date.accessioned | 2013-07-10T08:47:35Z | |
| dc.date.available | 2013-07-10T08:47:35Z | |
| dc.date.issued | 2007-07 | |
| dc.description.abstract | Context: Neurocysticercosis is a endemic disease in Nepal causing social and financial burden on society and developmental problem in children. Aims: To determine the efficacy of albendazole plus oral prednisolone in children with 1 or 2 ring-enhancing lesions (by CT) on resolution of lesions and recurrence of seizure. Setting and Design: Randomized controlled open trial. Methods and Materials: Children with 1 or 2 ring-enhancing lesions <20 mm in diameter on computed tomography scan, likely to have Neurocysticercosis, were assigned to treatment & control groups. Children assigned to the treatment group (n = 50) were given 2.0 mg/kg per day prednisolone orally for 5 days plus 15 mg/kg per day albendazole on third day for 28 days. Anti epileptic drugs were given to both groups {including Control group (n = 51)}. Statistical Analysis: The results were analysed with the use of Epi Info version 6.04 and Stata version;7 software. Results: The lesions resolved completely or partially in more children in the treated group compared with the control group (p = .04 & p = 0.03). The proportion of children who had seizures was significantly lower in the treated group compared with the control group at 6 months (10% versus 33%; p = .006) and 12 months (14% versus 38%; p = .003). Conclusion: Albendazole plus Prednisolone increased resolution of lesions on computed tomography scan and reduced the risk of subsequent recurrence of seizures among children with Neurocysticercosis. | en_US |
| dc.identifier.citation | Swain P K, Thapalial A, Das R N, Dhaliwal M S, Subedi K. Efficacy of Albendazole and Short-Course Prednisolone Treatment in Children with One or Two Ring-Enhancing Lesions of Neurocysticercosis: A Randomized Controlled Trial. Journal of Nepal Paediatric Society. 2007 Jul-Dec; 27(2): 60-63. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/147220 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.nepjol.info/index.php/JNPS/article/view/1410/1385 | en_US |
| dc.subject | Prednisolone | en_US |
| dc.subject | Albendazole | en_US |
| dc.subject | Neurocysticercosis and Children | en_US |
| dc.title | Efficacy of Albendazole and Short-Course Prednisolone Treatment in Children with One or Two Ring-Enhancing Lesions of Neurocysticercosis: A Randomized Controlled Trial. | en_US |
| dc.type | Article | en_US |