Synergy between verapamil and other multidrug -resistance modulators in model membranes.

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dc.contributor.authorCastaing, Madeleineen_US
dc.contributor.authorLoiseau, Alainen_US
dc.contributor.authorCornish-Bowden, Athelen_US
dc.date.accessioned2007-06-01en_US
dc.date.accessioned2009-06-01T15:09:51Z
dc.date.available2007-06-01en_US
dc.date.available2009-06-01T15:09:51Z
dc.date.issued2007-06-01en_US
dc.description.abstractVarious cationic lipophilic compounds can reverse the multidrug resistance of cancer cells. Possible interaction between these compounds, which are known as modulators, has been assessed by measuring leakage of Sulphan blue from anionic liposomes, induced both by verapamil alone and by verapamil in combination with diltiazem, quinine, thioridazine or clomipramine. An equation was derived to quantify the permeation doses and Hill coefficients of the drugs and mixtures between them by simultaneous fitting of the experimental data. The interaction was tested by two methods, the competition plot and the isobole method; both showed synergy between verapamil and each of diltiazem, quinine and thioridazine. The dose factor of potentiation for verapamil determined within membranes was 4.0 +/- 0.4 with diltiazem, 3.2 +/-0.4 with quinine and 2.4 +/- 0.3 with thioridazine. The results suggest that the effectiveness of reversing multidrug resistance may be increased with modulators such as verapamil and diltiazem that have a much greater effect in combination than what would be expected from their effects when considered separately.en_US
dc.description.affiliationFaculté de Pharmacie, 27, Boulevard Jean Moulin, 13385 Marseille, France. madeleine.castaing@dr13.cnrs.fren_US
dc.identifier.citationCastaing M, Loiseau A, Cornish-Bowden A. Synergy between verapamil and other multidrug -resistance modulators in model membranes. Journal of Biosciences. 2007 Jun; 32(4): 737-46en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111347
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Resistance, Multipleen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshLiposomesen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshPermeabilityen_US
dc.subject.meshVerapamil --pharmacologyen_US
dc.titleSynergy between verapamil and other multidrug -resistance modulators in model membranes.en_US
dc.typeJournal Articleen_US
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