The perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing cardiac surgery: A double-blinded randomized study

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dc.contributor.authorSoliman, Rabieen_US
dc.contributor.authorAbukhudair, Waliden_US
dc.date.accessioned2019-12-02T09:44:19Z
dc.date.available2019-12-02T09:44:19Z
dc.date.issued2019-07
dc.description.abstractObjective: The objective of this study was to assess the cardioprotective effect of magnesium sulfate in patients with left ventricular concentric hypertrophy undergoing cardiac surgery. Design: The study was a double-blinded randomized study. Setting: This study was conducted at a cardiac center. Patients: The study included 250 patients. Intervention: The study included two groups (each = 125): Group M – the patients who received magnesium sulfate infusion (15 mg/kg/h). The infusion was started 20 min before induction, during surgery, and the first postoperative 24 h. Group C – the patients who received an equal amount of normal saline. Measurements: The variables included troponin I level, creatinine kinase-MB (CK-MB) level, electrocardiograph (ECG) with automatic ST-segment analysis (leads II and V), E/A peak ratio, end-diastolic volume, cardiac index (CI), heart rate, mean arterial blood pressure (MAP), mean arterial pulmonary pressure (mPAP), pulmonary and systemic vascular resistances, and pharmacological and mechanical support. Main Results: The troponin I level, CK-MB, and ECG changes were lower in Group M than Group C (P < 0.05). The E/A peak ratio and end-diastolic volume increased in Group M than Group C (P < 0.05). There was a significant increase in the CI and a decrease in the heart rate, mPAP, pulmonary vascular resistances, and pharmacological and mechanical support in Group M compared to Group C (P < 0.05). There were minimal changes in the MAP and systemic vascular resistance in Group M compared to Group C (P < 0.05). Conclusion: The magnesium sulfate provides a cardioprotective effect in patients with concentric ventricular hypertrophy undergoing cardiac surgery. It decreases the incidence of perioperative myocardial infarction and arrhythmia. Furthermore, it decreases the requirement of pharmacological and mechanical support.en_US
dc.identifier.affiliationsDepartment of Anesthesia, Cairo University, Cairo, Egypt; Department of Cardiac Anesthesia, Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Cardiac Surgery, Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabiaen_US
dc.identifier.citationSoliman Rabie, Abukhudair Walid. The perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing cardiac surgery: A double-blinded randomized study. Annals of Cardiac Anaesthesia. 2019 Jul; 22(3): 246-253en_US
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/185836
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume22en_US
dc.source.urihttps://dx.doi.org/10.4103/aca.ACA_34_18en_US
dc.subjectAdult cardiac surgeryen_US
dc.subjectconcentric ventricular hypertrophyen_US
dc.subjectcreatinine kinase‑MB isoenzymeen_US
dc.subjectmagnesium sulfateen_US
dc.subjectmyocardial protectionen_US
dc.subjecttroponin Ien_US
dc.titleThe perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing cardiac surgery: A double-blinded randomized studyen_US
dc.typeJournal Articleen_US
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