Recent Advances on the Structure, Genomic Arrangement, Life Cycle, and Virus-Host Proteins Interactome of SARS CoV-2

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dc.contributor.authorAbebe, Endeshaw Chekolen_US
dc.contributor.authorDejenie, Tadesse Asmamawen_US
dc.date.accessioned2023-08-25T06:43:54Z
dc.date.available2023-08-25T06:43:54Z
dc.date.issued2022-09
dc.description.abstractNovel coronavirus disease of 2019 (COVID-19) is a highly contagious disease that has been recorded as a third global pandemic caused by the coronavirus (CoV) family in the past twenty years in the aftermath of severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). COVID 19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is transmitted by person-to-person transmission and it remains asymptomatic or presented with mild flu-like symptoms in most occasions, while in some instances, it may progress to severe life threatening and potentially fatal illnesses. This disease is now imposing immense negative influences across the world due to the highly contagious nature of the disease as well as due to the absence of effective treatment targeting the disease. This review addresses the recent advances on the structure and genomic arrangement of SARS-CoV-2 as well as the viral entry, replication and virus-host protein interactome that potentially contribute to cell infectivity, immune evasion, and viral spread. Unveiling the details of such aspects of SARS-CoV-2, therefore, possibly has paramount importance for discovering therapeutic targets.en_US
dc.identifier.affiliationsDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopiaen_US
dc.identifier.affiliationsDepartment of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopiaen_US
dc.identifier.citationAbebe Endeshaw Chekol, Dejenie Tadesse Asmamaw. Recent Advances on the Structure, Genomic Arrangement, Life Cycle, and Virus-Host Proteins Interactome of SARS CoV-2. International Journal of Applied Biology and Pharmaceutical Technology. 2022 Sept; 13(3): 19-32en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225566
dc.languageenen_US
dc.publisherApplied Biology and Pharmaceutical Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume13en_US
dc.source.urihttps://www.doi.org/10.26502/ijabpt.202117en_US
dc.subjectGenomic Arrangementen_US
dc.subjectLife Cycleen_US
dc.subjectSARS CoV-2en_US
dc.subjectStructureen_US
dc.subjectVirus-Host Protein Interactomeen_US
dc.titleRecent Advances on the Structure, Genomic Arrangement, Life Cycle, and Virus-Host Proteins Interactome of SARS CoV-2en_US
dc.typeJournal Articleen_US
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