Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis.

Simple item page
dc.contributor.authorIkehara, Ken_US
dc.date.accessioned2002-03-09en_US
dc.date.accessioned2009-06-01T14:28:38Z
dc.date.available2002-03-09en_US
dc.date.available2009-06-01T14:28:38Z
dc.date.issued2002-03-09en_US
dc.description21 references.en_US
dc.description.abstractWe have investigated the origin of genes, the genetic code, proteins and life using six indices (hydropathy, alpha-helix, beta-sheet and beta-turn formabilities, acidic amino acid content and basic amino acid content) necessary for appropriate three-dimensional structure formation of globular proteins. From the analysis of microbial genes, we have concluded that newly-born genes are products of nonstop frames (NSF) on antisense strands of microbial GC-rich genes [GC-NSF(a)] and from SNS repeating sequences [(SNS)n] similar to the GC-NSF(a) (S and N mean G or C and either of four bases, respectively). We have also proposed that the universal genetic code used by most organisms on the earth presently could be derived from a GNC-SNS primitive genetic code. We have further presented the [GADV]-protein world hypothesis of the origin of life as well as a hypothesis of protein production, suggesting that proteins were originally produced by random peptide formation of amino acids restricted in specific amino acid compositions termed as GNC-, SNS- and GC-NSF(a)-0th order structures of proteins. The [GADV]-protein world hypothesis is primarily derived from the GNC-primitive genetic code hypothesis. It is also expected that basic properties of extant genes and proteins could be revealed by considerations based on the scenario with four stages.en_US
dc.description.affiliationDepartment of Chemistry, Faculty of Science, Nara Women's University, Kita-uoya-nishi-machi, Nara, Nara 630-8506, Japan. ikehara@cc.nara-wu.ac.jpen_US
dc.identifier.citationIkehara K. Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis. Journal of Biosciences. 2002 Mar; 27(2): 165-86en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110855
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAmino Acids --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiogenesisen_US
dc.subject.meshEvolutionen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshExons --geneticsen_US
dc.subject.meshGenesen_US
dc.subject.meshGenetic Codeen_US
dc.subject.meshMitochondria --geneticsen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshProtein Structure, Secondaryen_US
dc.subject.meshProteins --chemistryen_US
dc.subject.meshRNA --geneticsen_US
dc.titleOrigins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Biosciences