Histopathology of skin lesions in chronic arsenic toxicity--grading of changes and study of proliferative markers.

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dc.contributor.authorPaul, P Cen_US
dc.contributor.authorChattopadhyay, Aen_US
dc.contributor.authorDutta, S Ken_US
dc.contributor.authorMazumder, D Nen_US
dc.contributor.authorSantra, Aen_US
dc.date.accessioned2000-07-24en_US
dc.date.accessioned2009-05-29T11:18:59Z
dc.date.available2000-07-24en_US
dc.date.available2009-05-29T11:18:59Z
dc.date.issued2000-07-24en_US
dc.description.abstractChronic arsenic toxicity (CAT) manifests predominantly as cutaneous lesions in the form of melanosis, keratosis and neoplastic changes. We have studied skin biopsies from 42 patients of CAT. Histological study of H/E stained sections showed--hyperkeratosis in 13, parakeratosis in 13, acanthosis in 12, papillomatosis in 24, elongation of reteridges in 21, increased basal pigmentation in 27 and dysplastic changes in 8 cases. Squamous cell carcinoma was present in 2, basisquamous in 1 and basal cell carcinoma in 1 case. Changes of skin lesions after drug DMSA and DMPS therapy compared to placebo were studied. The result was inconclusive. Proliferative activity of skin lesions in CAT were studied by AgNOR stain to assess the biological behaviour of the lesions. AgNOR score showed--normal control 1.08, benign changes (e.g. Hyperkeratosis, parakeratosis, acanthosis, papillomatosis etc.) without dysplasia--1.35, mild to moderate dysplasia--1.735, severe dysplasia--3.0 and carcinoma--3.56. Thus, AgNOR score gives some idea on the biological behaviour of CAT lesions. It is suggested that AgNOR staining should be done regularly along with H&E staining for proper assessment of the cases.en_US
dc.description.affiliationDepartment of Pathology, University College of Medicine and IPGMER, Calcutta.en_US
dc.identifier.citationPaul PC, Chattopadhyay A, Dutta SK, Mazumder DN, Santra A. Histopathology of skin lesions in chronic arsenic toxicity--grading of changes and study of proliferative markers. Indian Journal of Pathology & Microbiology. 2000 Jul; 43(3): 257-64en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73381
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshArsenic --analysisen_US
dc.subject.meshArsenic Poisoning --pathologyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCarcinoma --chemically induceden_US
dc.subject.meshCell Divisionen_US
dc.subject.meshChilden_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratosis --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshMelanosis --chemically induceden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSkin --pathologyen_US
dc.subject.meshSkin Neoplasms --chemically induceden_US
dc.titleHistopathology of skin lesions in chronic arsenic toxicity--grading of changes and study of proliferative markers.en_US
dc.typeJournal Articleen_US
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