Field performance of malaria rapid diagnostic test for the detection of Plasmodium falciparum infection in Odisha State, India.

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dc.contributor.authorSahu, S S
dc.contributor.authorGunasekaran, K
dc.contributor.authorJambulingam, P
dc.date.accessioned2016-08-04T06:10:17Z
dc.date.available2016-08-04T06:10:17Z
dc.date.issued2015-12
dc.description.abstractBackground & objectives: Rapid diagnostic tests (RDTs) have become an essential surveillance tool in the malaria control programme in India. The current study aimed to assess the performance of ParaHIT-f, a rapid test in diagnosis of Plasmodium falciparum infection through detecting its specific antigen, histidine rich protein 2 (PfHRP-2), in Odisha State, India. Methods: The study was undertaken in eight falciparum malaria endemic southern districts of Odisha State. Febrile patients included through active case detection, were diagnosed by Accredited Social Health Activists (ASHAs) for P. falciparum infection using the RDT, ParaHIT-f. The performance of ParaHIT-f was evaluated using microscopy as the gold standard. Results: A total of 1030 febrile patients were screened by both microscopy and the RDT for P. falciparum infection. The sensitivity of ParaHIT-f was 63.6% (95% CI: 56.0-70.6) and specificity was 98.9% (95% CI: 97.9-99.5), with positive and negative predictive values (PPV and NPV) of 92.6% (95% CI: 86.0-96.3) and 93.0% (95% CI: 91.0-94.5), respectively. When related to parasitaemia, the RDT sensitivity was 47.8% at the low parasitaemia of 4 to 40 parasites/μl of blood. Interpretation & conclusions: The results showed that the performance of the RDT, ParaHIT-f, was not as sensitive as microscopy in detecting true falciparum infections; a high specificity presented a low frequency of false-positive RDT results. The sensitivity of ParaHIT-f was around 60 per cent. It is, therefore, essential to improve the efficiency (sensitivity) of the kit so that the true falciparum infections will not be missed especially in areas where P. falciparum has been the predominant species causing cerebral malaria.en_US
dc.identifier.citationSahu S S, Gunasekaran K, Jambulingam P. Field performance of malaria rapid diagnostic test for the detection of Plasmodium falciparum infection in Odisha State, India. Indian Journal of Medical Research. 2015 Dec; 142(Suppl_1): 52-58.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176390
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795347/en_US
dc.subjectMicroscopyen_US
dc.subjectOdishaen_US
dc.subjectParaHIT-fen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectP. vivaxen_US
dc.subjectrapid diagnostic testen_US
dc.titleField performance of malaria rapid diagnostic test for the detection of Plasmodium falciparum infection in Odisha State, India.en_US
dc.typeArticleen_US
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