Secretion of metastasis related gangliosides by mouse B16-melanoma in circulation in vivo and in culture media in vitro.

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dc.contributor.authorSaha, Sen_US
dc.contributor.authorMohanty, K Cen_US
dc.date.accessioned2009-05-28T13:27:26Z
dc.date.available2009-05-28T13:27:26Z
dc.date.issued2004-10-30en_US
dc.description.abstractMouse B16LuF1 melanoma cells of lower metastatic potential to lung were treated in vitro with same concentration (50 microM) of gangliosides prepared from plasma of mice bearing lung metastasis of B16LuF5, B16LuF9 or B16LuF10 melanoma cell lines of increasing metastatic potential to lung (LuF1 < LuF5 < LuF9 < LuF10) and injected to normal mice through tail vein. The number of metastatic tumor nodules formed in lung increased gradually in mice receiving B16LuF5, B16LuF9 and B16LuF10-ganglioside-treated B16LuF1 cells compared to mice receiving B16LuF1 cells without any ganglioside treatment. Similarly, mouse B16LuF1 melanoma cells treated in vitro with 50 microM concentration of gangliosides prepared from spent culture media of B16LuF5, B16LuF9 or B16LuF10 cells cultured in vitro were injected to normal mice through tail vein. The number of metastatic tumor nodules formed in lung increased gradually in mice receiving B16LuF5, B16LuF9 and B16LuF10-ganglioside-treated B16LuF1 cells compared to mice receiving B16LuF1 cells without any ganglioside treatment. The results indicated that metastasis-associated gangliosides present in plasma and culture media of B16-melanoma of increasing metastatic potential to lung enhanced metastatic potential of B16LuF1 cells. The increasing concentration of metastasis-associated gangliosides present in plasma and in culture media of B16-melanoma of increasing metastatic potential possibly determined increase in metastatic potential of B16LuF1-melanoma cells.en_US
dc.description.affiliationDepartment of Metabolic Regulation, Chittaranjan National Cancer Institute, Kolkata, India. sahasandip51@rediffmail.comen_US
dc.identifier.citationSaha S, Mohanty KC. Secretion of metastasis related gangliosides by mouse B16-melanoma in circulation in vivo and in culture media in vitro. Indian Journal of Experimental Biology. 2004 Oct; 42(10): 976-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59433
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCulture Media, Conditioneden_US
dc.subject.meshGangliosides --blooden_US
dc.subject.meshLung Neoplasms --secondaryen_US
dc.subject.meshMelanoma, Experimental --secondaryen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.titleSecretion of metastasis related gangliosides by mouse B16-melanoma in circulation in vivo and in culture media in vitro.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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