Biocompatibility of nanometre scale porous anodic aluminium oxide membranes towards the RK 13 epithelial cell line: A preliminary study.

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dc.contributor.authorPoinern, Gérrard Eddy Jai
dc.contributor.authorLe, Xuan Thi
dc.contributor.authorO’Dea, Mark
dc.contributor.authorFawcett, Derek
dc.date.accessioned2015-11-26T09:20:00Z
dc.date.available2015-11-26T09:20:00Z
dc.date.issued2015-07
dc.description.abstractBackground: This study for the first time examines the biomedical potential of using anodic aluminium oxide (AAO) for culturing Oryctolagus cuniculus (European Rabbit) Kidney (RK-13) epithelial cells. Methods: The cellular response of RK-13 cells towards in-house synthesised AAO membranes, a commercially available membrane and glass controls were investigated by examining cell adhesion, morphology and proliferation. The in-house membranes were anodized using a two-step procedure to produce a highly ordered hexagonal pore and channel structure. Results: Cell proliferation over a 48 h period indicated that the AAO membranes were more than comparable with the glass control substrates. Subsequent microscopy observations revealed evidence of focal adhesion sites and cellular extensions interacting with the underlining porous membrane surface structure. Conclusions: The study has shown that AAO membranes have the potential to culture RK-13 cells and indicate a possible tissue engineering technique for producing tissues.en_US
dc.identifier.citationPoinern Gérrard Eddy Jai, Le Xuan Thi, O’Dea Mark, Fawcett Derek. Biocompatibility of nanometre scale porous anodic aluminium oxide membranes towards the RK 13 epithelial cell line: A preliminary study. International Journal of Research in Medical Sciences. 2015 July; 3(7): 1583-1588.en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166294
dc.language.isoenen_US
dc.source.urihttps://www.msjonline.org/?mno=189306en_US
dc.subjectNano-porous Anodic Aluminium Oxideen_US
dc.subjectRK-13en_US
dc.subjectCell Adhesionen_US
dc.subjectCell Proliferationen_US
dc.titleBiocompatibility of nanometre scale porous anodic aluminium oxide membranes towards the RK 13 epithelial cell line: A preliminary study.en_US
dc.typeArticleen_US
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