The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting.

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dc.contributor.authorSundar, Ayya Syama
dc.contributor.authorKodali, Rajeshkumar
dc.contributor.authorSulaiman, Sajith
dc.contributor.authorRavullapalli, Harish
dc.contributor.authorKarthekeyan, Ranjith
dc.contributor.authorVakamudi, Mahesh
dc.date.accessioned2012-07-18T09:12:33Z
dc.date.available2012-07-18T09:12:33Z
dc.date.issued2012-01
dc.description.abstractThe clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.en_US
dc.identifier.citationSundar Ayya Syama, Kodali Rajeshkumar, Sulaiman Sajith, Ravullapalli Harish, Karthekeyan Ranjith, Vakamudi Mahesh. The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting. Annals of Cardiac Anaesthesia. 2012 Jan; 15(1): 18-25.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139629
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=1;spage=18;epage=25;aulast=Sundaren_US
dc.subjectOff-pump coronary artery bypass graftingen_US
dc.subjectintubation responseen_US
dc.subjectoff-pumpen_US
dc.subjectpregabalinen_US
dc.subject.meshAged
dc.subject.meshAnalgesics, Opioid --therapeutic use
dc.subject.meshCoronary Artery Bypass, Off-Pump
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshFentanyl --therapeutic use
dc.subject.meshHemodynamics --drug effects
dc.subject.meshHumans
dc.subject.meshIntubation, Intratracheal
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshStress, Psychological --prevention & control
dc.subject.meshgamma-Aminobutyric Acid --analogs & derivatives
dc.subject.meshgamma-Aminobutyric Acid --therapeutic use
dc.titleThe effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting.en_US
dc.typeArticleen_US
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