Cardiac enzyme levels in myocardial dysfunction in newborns with perinatal asphyxia.

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dc.contributor.authorRajakumar, P Sen_US
dc.contributor.authorBhat, B Vishnuen_US
dc.contributor.authorSridhar, M Gen_US
dc.contributor.authorBalachander, Jen_US
dc.contributor.authorKonar, B Cen_US
dc.contributor.authorNarayanan, Pen_US
dc.contributor.authorChetan, Gen_US
dc.date.accessioned2008-12-15en_US
dc.date.accessioned2009-05-30T14:22:11Z
dc.date.available2008-12-15en_US
dc.date.available2009-05-30T14:22:11Z
dc.date.issued2008-12-15en_US
dc.description.abstractOBJECTIVE: To study the usefulness of cardiac enzymes in evaluating myocardial damage in perinatal asphyxia. METHODS: Thirty term babies with perinatal asphyxia and without any congenital malformations were selected as cases. They were compared with thirty healthy term babies without asphyxia. Myocardial dysfunction was evaluated using clinical, electrocardiography, echocardiography and cardiac enzymes i.e, troponin-T and CK-MB levels. RESULTS: Among the 30 cases 23 had evidence of myocardial involvement while one baby in the control group had ECG evidence compatible with cardiac involvement. Cardiac enzymes were significantly increased in babies with perinatal asphyxia. The mean level of C-troponin-T among cases and controls were 0.22+/-0.28 and 0.003+/-0.018 while CK-MB levels were 121+/-77.4 IU/L and 28.8 +/- 20.2 IU/L respectively. C-troponin-T had higher sensitivity and specificity compared to CK-MB levels. Moreover, C troponin-T levels correlated well with severity and outcome in babies with perinatal asphyxia. CONCLUSION: C-Tropopnin assay is useful in evaluating the severity of myocardial damage and outcome in perinatal asphyxia.en_US
dc.description.affiliationDepartment of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.en_US
dc.identifier.citationRajakumar PS, Bhat BV, Sridhar MG, Balachander J, Konar BC, Narayanan P, Chetan G. Cardiac enzyme levels in myocardial dysfunction in newborns with perinatal asphyxia. Indian Journal of Pediatrics. 2008 Dec; 75(12): 1223-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82590
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAsphyxia Neonatorum --complicationsen_US
dc.subject.meshCardiomyopathies --diagnosisen_US
dc.subject.meshCreatine Kinase, MB Form --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMyocardium --enzymologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTroponin T --blooden_US
dc.titleCardiac enzyme levels in myocardial dysfunction in newborns with perinatal asphyxia.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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