Partial Purification and Characterization of Albain 1, a Triterpene with Antimicrobial Activity, from the Wood Extract of Avicennia alba Blume

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dc.contributor.authorChoudhury, Moumitaen_US
dc.contributor.authorMukherjee, Kalishankaren_US
dc.contributor.authorArnab Deen_US
dc.contributor.authorSamanta, Amaleshen_US
dc.contributor.authorRoy, Amiten_US
dc.date.accessioned2020-11-18T10:30:13Z
dc.date.available2020-11-18T10:30:13Z
dc.date.issued2020-03
dc.description.abstractSecondary metabolites of plants are important resources for development of new drugs. Mangrove plants are very well known sources of wide variety of secondary metabolites. Many of these secondary metabolites from mangroves have been found to possess significant biological activities where human health is concerned. Avicennia albaBlume is one such mangrove plant with reports of having many such secondary metabolites of clinical and commercial interests.Aim:To evaluate antimicrobial activity potential of A. albawood extract and to isolate new bioactive constituent(s) responsible for such biological activity.Methodology: Preliminary screenings of antimicrobial activities in different organic solvent extracts of A. albawood tissue were done by TLC-bioautography method and phytochemical nature of the antimicrobial constituent(s) in the extracts have been studied. One compound exhibiting significant antimicrobial activity, named as Albain 1, has been isolated. MIC value has been determined for Albain 1. The purity and structure of Albain 1 have been determined by HPLC, 1HNMR, FTIR and HRMS etc. analysis.Results: 1HNMR, FTIR and HRMS analysis have found out that the isolated compound Albain1 is a triterpene and the molecular formula is C30H48O4.It has exhibited remarkable antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Bacillus pumilas (MIC 125μg / ml).Conclusion:The observed antimicrobial activity of the isolated fraction of A. albaoffer great potentials in pharmaceutical industries.en_US
dc.identifier.affiliationsDepartment of Biotechnology, Visva-Bharati University, Santiniketan-731235, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Chemistry, Visva-Bharati University, Santiniketan-731235, West Bengal, Indiaen_US
dc.identifier.affiliationsDivision of Microbiology, Department of Pharmaceutical Technology, Jadavpur University,Kolkata-700032, West Bengal, Indiaen_US
dc.identifier.affiliationsDivision of Microbiology, Department of Pharmaceutical Technology, Jadavpur University,Kolkata-700032, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Visva-Bharati University, Santiniketan-731235, West Bengal, Indiaen_US
dc.identifier.citationChoudhury Moumita, Mukherjee Kalishankar, Arnab De, Samanta Amalesh, Roy Amit. Partial Purification and Characterization of Albain 1, a Triterpene with Antimicrobial Activity, from the Wood Extract of Avicennia alba Blume. Journal of Pharmaceutical Research International. 2020 Mar; 32(2): 38-48en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215811
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i230402en_US
dc.subjectAntimicrobial activity;Avicennia alba Blume;secondary metabolites;MIC.en_US
dc.titlePartial Purification and Characterization of Albain 1, a Triterpene with Antimicrobial Activity, from the Wood Extract of Avicennia alba Blumeen_US
dc.typeJournal Articleen_US
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