Changes in phospholipids and acetylcholinesterase during early phase of injury to spinal cord--an experimental study in rats.

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dc.contributor.authorCherian, Len_US
dc.contributor.authorKuruvilla, Aen_US
dc.contributor.authorChandy, M Jen_US
dc.contributor.authorAbraham, Jen_US
dc.date.accessioned1996-04-01en_US
dc.date.accessioned2009-06-01T08:11:12Z
dc.date.available1996-04-01en_US
dc.date.available2009-06-01T08:11:12Z
dc.date.issued1996-04-01en_US
dc.description.abstractInjury to spinal cord was produced in rats by the clip compression technique by placing the aneurysm clip extradurally for 30 seconds. The traumatised spinal segment and the adjoining upper segment were used for biochemical estimations. Motor function of the injured rats was evaluated using the inclined plane. Phospholipid phosphorus values were significantly decreased in the injured spinal segment at 24 hrs. AchE activity was also decreased in the traumatised segment one week after injury. Dexamethasone and verapamil reversed the changes in AchE activity at the end of one week. At the one week assessment period, aneurysm clipped rats showed a decrease in the maximum angle in the inclined plane. Dexamethasone and verapamil treated rats showed improvement in the neurologic function, neurologic recovery was better in the dexamethasone treated group.en_US
dc.description.affiliationDepartment of Pharmacology, Christian Medical College and Hospital, Vellore.en_US
dc.identifier.citationCherian L, Kuruvilla A, Chandy MJ, Abraham J. Changes in phospholipids and acetylcholinesterase during early phase of injury to spinal cord--an experimental study in rats. Indian Journal of Physiology and Pharmacology. 1996 Apr; 40(2): 134-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108722
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcetylcholinesterase --metabolismen_US
dc.subject.meshAneurysm --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents --pharmacologyen_US
dc.subject.meshCalcium --metabolismen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshDexamethasone --pharmacologyen_US
dc.subject.meshExtracellular Space --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSpinal Cord Injuries --enzymologyen_US
dc.subject.meshVerapamil --pharmacologyen_US
dc.titleChanges in phospholipids and acetylcholinesterase during early phase of injury to spinal cord--an experimental study in rats.en_US
dc.typeJournal Articleen_US
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