Anti-inflammatory and Immuno-modulatory Effects of Capparis spinosa Flower Bud Extract

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dc.contributor.authorKernouf, Nassimaen_US
dc.contributor.authorBouriche, Hamamaen_US
dc.contributor.authorKada, Seoussenen_US
dc.contributor.authorMessaoudi, Dalilaen_US
dc.contributor.authorAssaf, Areej M.en_US
dc.contributor.authorSenator, Abderrahmaneen_US
dc.date.accessioned2019-12-06T09:18:03Z
dc.date.available2019-12-06T09:18:03Z
dc.date.issued2018-03
dc.description.abstractAims: Capparis spinosa L. is a plant widely used in traditional medicine for its different purpose including the anti-inflammatory properties. The aim of this study was to evaluate the anti-inflammatory properties of this plant and to define its possible mechanism of action by verifying its effect on the production of some inflammatory mediators. Methodology: The anti-inflammatory activity of Capparis spinosa bud methanolic extract was evaluated in vivo, using paw edema and air pouch inflammation models. In vitro, the ability of the extract to modulate the production of some pro and anti-inflammatory mediators such as TNF-α, IL-1β, IL-8 and IL-10 released from peripheral blood mononuclear cells stimulated by concanavalin A was evaluated. Moreover, the effect of the extract on LTB4 and superoxide anion released from neutrophils was tested. Results: Results showed that the oral administration of 200 and 400 mg/kg of Capparis spinosa methanolic extract reduced significantly carrageenan-induced paw edema. Above 2 h, both doses of the extract exerted a significant (P < 0.001) anti-edematous effect, with 52%-69%. In addition, this extract inhibited the neutrophil migration into the air pouch. The inhibition exerted by 1 mg/pouch of the extract (48.92%) was better than that exerted by indomethacin, used as reference. On the other hand, the extract inhibited significantly the production of TNF-α, IL-1β, LTB4 and superoxide anion generation. At 100 µg/mL, the inhibition values were 21.28%, 38.04%, 20.84% and 71.16%, respectively. In contrast, the extract did not show any significant effect on the release of IL-8 and IL-10. Conclusion: Capparis spinosa bud extract inhibited the inflammatory process by modulating the pro-inflammatory mediator release. Thus this extract can offer a new therapeutic strategy for the treatment of inflammatory disorders.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Natural and Life Science, University Ferhat Abbas, Sétif 1, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Natural and Life Science, University Ferhat Abbas, Sétif 1, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Natural and Life Science, University Ferhat Abbas, Sétif 1, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Natural and Life Science, University Ferhat Abbas, Sétif 1, Algeria.en_US
dc.identifier.affiliationsDepartment of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Natural and Life Science, University Ferhat Abbas, Sétif 1, Algeria.en_US
dc.identifier.affiliationsnullen_US
dc.identifier.affiliationsnullen_US
dc.identifier.affiliationsnullen_US
dc.identifier.affiliationsnullen_US
dc.identifier.citationKernouf Nassima, Bouriche Hamama, Kada Seoussen, Messaoudi Dalila, Assaf Areej M., Senator Abderrahmane. Anti-inflammatory and Immuno-modulatory Effects of Capparis spinosa Flower Bud Extract. Annual Research & Review in Biology. 2018 Mar; 25(3): 1-11en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187819
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume25en_US
dc.source.urihttps://doi.org/10.9734/ARRB/2018/40189en_US
dc.subjectAnti-inflammatoryen_US
dc.subjectCapparis spinosaen_US
dc.subjectedemaen_US
dc.subjectcytokinesen_US
dc.subjectleukotrienesen_US
dc.subjectsuperoxide anionen_US
dc.titleAnti-inflammatory and Immuno-modulatory Effects of Capparis spinosa Flower Bud Extracten_US
dc.typeJournal Articleen_US
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