Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats.

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dc.contributor.authorChaturvedi, Aditien_US
dc.contributor.authorKumar, M Mohanen_US
dc.contributor.authorBhawani, Gen_US
dc.contributor.authorChaturvedi, Harishen_US
dc.contributor.authorKumar, Mohanen_US
dc.contributor.authorGoel, R Ken_US
dc.date.accessioned2007-04-08en_US
dc.date.accessioned2009-06-01T08:15:37Z
dc.date.available2007-04-08en_US
dc.date.available2009-06-01T08:15:37Z
dc.date.issued2007-04-08en_US
dc.description.abstractEugenia jambolana (Jamun) fruit has been reported to give soothing effect on human digestive system. Present study includes the effect of ethanolic extract of seeds of E. jambolana (EJE) against gastric ulcers induced by 2 h cold restraint stress (CRS), aspirin (ASP, 200 mg/kg, 4 h), 95% ethanol (EtOH, 1 ml/200 g, 1 h) and 4 h pylorus ligation (PL) in rats. To ascertain the mechanism of action of EJE, its effect was studied on mucosal offensive acid-pepsin secretion, lipid peroxidation (LPO, free radical) and defensive mucin secretion, cell proliferation, glycoprotein and glutathione (GSH, an antioxidant). Acute and subacute toxicity studies were also conducted for the safety profile of Eugenia jambolana. EJE 200 mg/kg, when administered orally for 10 days in rats was found to reduce the ulcer index in all gastric ulcer models. It tended to decrease acid-pepsin secretion, enhanced mucin and mucosal glycoprotein and decreased cell shedding but had no effect on cell proliferation. It showed antioxidant properties indicated by decrease in LPO and increase in GSH levels in the gastric mucosa of rats. Acute toxicity study indicated LD50 to be more than 10 times (>2000 mg/kg) of the effective ulcer protective dose while subactue toxicity study (>1000 mg/kg) indicated no significant change in the general physiological and haematological parameters, liver and renal function tests. The result of the present study indicates that E. jambolana seed has gastro-protective properties mainly through promotion of mucosal defensive factors and antioxidant status and decreasing lipid peroxidation.en_US
dc.description.affiliationDepartment of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationChaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, Goel RK. Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian Journal of Physiology and Pharmacology. 2007 Apr-Jun; 51(2): 131-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108777
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agents --administration & dosageen_US
dc.subject.meshAspirinen_US
dc.subject.meshCell Proliferation --drug effectsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEthanol --chemistryen_US
dc.subject.meshEugenia --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPlant Extracts --administration & dosageen_US
dc.subject.meshPlants, Medicinal --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSeeds --chemistryen_US
dc.subject.meshStomach Ulcer --chemically induceden_US
dc.subject.meshStress, Physiologicalen_US
dc.titleEffect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats.en_US
dc.typeJournal Articleen_US
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