Fatal meningitis caused by vancomycin-resistant enterococci: Report of two cases from south India.

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dc.contributor.authorPraharaj, I
dc.contributor.authorSujatha, S
dc.contributor.authorParija, S C
dc.contributor.authorGopalakrishnan, M S
dc.date.accessioned2012-12-18T09:26:37Z
dc.date.available2012-12-18T09:26:37Z
dc.date.issued2012-04
dc.description.abstractVancomycin-resistant enterococci rarely cause meningitis and present a therapeutic challenge. Antimicrobial susceptibility testing was done for strains of Enterococcus species isolated from CSF samples of patients with meningitis by phenotypic methods. Multiplex polymerase chain reaction was performed to determine the genetic basis of vancomycin resistance of such isolates. We report here two cases of enterococcal meningitis caused by vancomycin-resistant Enterococcus species. One of the isolates was identified as Enterococcus faecalis and the other as Enterococcus gallinarum. We also report the simultaneous presence of vanC1 and vanA resistance genes in the strain of E. gallinarum. To the best of our knowledge, this is the first report of vanA resistance gene in an isolate of E. gallinarum from the Indian subcontinent. This is also the first Indian report of vancomycin-resistant Enterococcus causing meningitis.en_US
dc.identifier.citationPraharaj I, Sujatha S, Parija S C, Gopalakrishnan M S. Fatal meningitis caused by vancomycin-resistant enterococci: Report of two cases from south India. Indian Journal of Medical Microbiology. 2012 Apr-June; 30(2): 242-245.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143957
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2012;volume=30;issue=2;spage=242;epage=245;aulast=Praharajen_US
dc.subjectEnterococcusen_US
dc.subjectmultiplex PCRen_US
dc.subjectmeningitisen_US
dc.subjectresistanceen_US
dc.subjectvancomycinen_US
dc.subject.meshAged
dc.subject.meshAnti-Bacterial Agents --pharmacology
dc.subject.meshCerebrospinal Fluid --microbiology
dc.subject.meshDNA, Bacterial --genetics
dc.subject.meshEnterococcus --classification
dc.subject.meshEnterococcus --drug effects
dc.subject.meshEnterococcus --isolation & purification
dc.subject.meshFatal Outcome
dc.subject.meshFemale
dc.subject.meshGenes, Bacterial
dc.subject.meshGram-Positive Bacterial Infections --diagnosis
dc.subject.meshGram-Positive Bacterial Infections --mortality
dc.subject.meshGram-Positive Bacterial Infections --pathology
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshMale
dc.subject.meshMeningitis, Bacterial --diagnosis
dc.subject.meshMeningitis, Bacterial --mortality
dc.subject.meshMeningitis, Bacterial --pathology
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMiddle Aged
dc.subject.meshMultiplex Polymerase Chain Reaction
dc.subject.meshVancomycin Resistance
dc.titleFatal meningitis caused by vancomycin-resistant enterococci: Report of two cases from south India.en_US
dc.typeArticleen_US
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