Familial germ cell tumor.

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dc.contributor.authorCyriac, Sanju
dc.contributor.authorRajendranath, Rejeev
dc.contributor.authorLouis, A Robert
dc.contributor.authorSagar, T G
dc.date.accessioned2012-07-12T06:04:45Z
dc.date.available2012-07-12T06:04:45Z
dc.date.issued2012-01
dc.description.abstractFamilial testicular germ cell tumors are well known in literature. Only few cases are reported where both brother and sister of the same family suffered from germ cell malignancies. We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presence of germ cell malignancies in the siblings of different sex in the same family points toward a genetic susceptibility. Literature review revealed only six similar cases. A discussion regarding the rare occurrence of familial germ cell malignancies with the affected family members may be worthwhile.en_US
dc.identifier.citationCyriac Sanju, Rajendranath Rejeev, Louis A Robert, Sagar T G. Familial germ cell tumor. Indian Journal of Human Genetics. 2012 Jan; 18(1): 119-121.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139457
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385167/en_US
dc.subjectFamilialen_US
dc.subjectgeneticsen_US
dc.subjectgerm cell tumoren_US
dc.subject.meshAdolescent
dc.subject.meshDysgerminoma --etiology
dc.subject.meshDysgerminoma --genetics
dc.subject.meshFemale
dc.subject.meshFamily
dc.subject.meshGerminoma --etiology
dc.subject.meshGerminoma --genetics
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeoplasms, Germ Cell and Embryonal --etiology
dc.subject.meshNeoplasms, Germ Cell and Embryonal --genetics
dc.subject.meshSiblings
dc.subject.meshTesticular Neoplasms --etiology
dc.subject.meshTesticular Neoplasms --genetics
dc.titleFamilial germ cell tumor.en_US
dc.typeArticleen_US
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