Urinary Crosslinked N-telopeptides of type I collagen (NTx) among Reproductive and Post-menopausal Thai women
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2010-04-01
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The Thai Journal of Orthopaedic Surgery
Abstract
Purpose: To study the level of Urinary Crosslinked N-telopeptides of type I collagen (Urinary NTx) in reproductive and postmenopausal Thai women and their correlation with bone mineral density (BMD) and duration after menopause.Methods: Second or third void morning urine samples were collected in 48 reproductive women and 42 postmenopausal women. Urinary NTx was measured by competitive-inhibition ELISA and corrected with spot urine creatinine. BMD was measured in all postmenopausal participants.Results: The mean value of Urinary NTx in reproductive women was 36.19 nanomoles of bone collagen equivalents per millimole of Creatinine (nM BCE/mM Cr), standard deviation = 25.18 with 95% confidence interval = 28.88 to 43.50 nM BCE/mM Cr. The mean value of Urinary NTx in postmenopausal women was 58.89 nM BCE/mM Cr, standard deviation = 26.93 with 95% confidence interval = 50.50 to 67.28 nM BCE/mM Cr. Neither BMD nor duration after menopause is significantly correlated with Urinary NTx.Conclusion: Urinary NTx increased with age in Thai women (p
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The Thai Journal of Orthopaedic Surgery; Volume 34 Number 2 April 2010; 6 - 10