Relationship between periodontal treatment and production of interleukin-6 and tumor necrosis factor-alpha from monocyte of chronic periodontitis patients
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2010-11-03
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Khon Kaen University Dental Journal
Abstract
The purpose of this study was to evaluate the relationship between periodontal treatment and production of interlukin-6 and tumor necrosis factor-alpha by circulating monocytes. Thirty-six systemically healthy subjects, who diagnosed as chronic periodontitis, were enrolled in this study. Peripheral blood was obtained from every subject at 5 different phases; before treatment, immediately after treatment and 1, 3 and 6 months post-treatment. The treatment was using one of the periodontal-treatment methods which have clinical reported about reducing inflammation and bacterial amount throughout the 6 months after treatment. All subjects had shown significant improvement in clinical parameters after treatment. When data was analyzed, based on total number of monocytes in peripheral blood and production, there was no difference in the number of monocytes and the total leukocytes from the periods of treatment. Spontaneous production of both interleukin-6 and tumor necrosis factor-alpha from the monocytes obtained before the treatment was significantly greater than those obtained at the follow up periods. Furthermore, the interleukin-6, stimulated with interleukin-1 at before treatment, which produced by monocytes was also significantly greater than those obtained at 1 and 3 months after treatment. The present study suggests that periodontal inflammation may activate circulating monocytes, and such activation could be reduced by the periodontal therapy.
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Khon Kaen University Dental Journal; Vo.12 No. 1 Jan - June 2009