Effect of chitosan on lipid levels when administered concurrently with atorvastatin--a placebo controlled study.

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dc.contributor.authorGuha, Sen_US
dc.contributor.authorPal, S Ken_US
dc.contributor.authorChatterjee, Nen_US
dc.contributor.authorSarkar, Gen_US
dc.contributor.authorPal, Sen_US
dc.contributor.authorGuha, Sharmilaen_US
dc.contributor.authorBasu, A Ken_US
dc.contributor.authorBanerjee, Ren_US
dc.date.accessioned2005-08-21en_US
dc.date.accessioned2009-05-31T17:51:10Z
dc.date.available2005-08-21en_US
dc.date.available2009-05-31T17:51:10Z
dc.date.issued2005-08-21en_US
dc.description.abstractIn a placebo controlled trialthe lipid lowering effects of chitosan, a unique dietary fibre, was assessed when given along with atorvastatin 10 mg in patients with chronic coronary heart disease. Altogether 100 patients were studied. They were randomly allocated in two groups of 50 patients each. Patients of group A received atorvastatin 10 mg before dinner plus 2 g/day chitosan in two divided doses. The groupB patients received atorvastatin 10 mg plus placebo. Patients were followed up for a period of 6 weeks. There was significant reduction in mean body weight in group A patients (3.14% versus 1,29% of body weight, p<0.05). There was also a significant rise in HDL cholesterol value (3.8% versus 1.07%, p=0.02) in group A patients. However, there was no significant reduction in the mean values of total cholesterol, LDL cholesterol and triglyceride in the two groups, although group A patients showed marginally lower values.en_US
dc.description.affiliationDepartment of Cardiology, Medical College, Kolkata.en_US
dc.identifier.citationGuha S, Pal SK, Chatterjee N, Sarkar G, Pal S, Guha S, Basu AK, Banerjee R. Effect of chitosan on lipid levels when administered concurrently with atorvastatin--a placebo controlled study. Journal of the Indian Medical Association. 2005 Aug; 103(8): 418, 420en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/105432
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAnticholesteremic Agents --therapeutic useen_US
dc.subject.meshChitosan --therapeutic useen_US
dc.subject.meshCholesterol, HDL --blooden_US
dc.subject.meshCholesterol, LDL --blooden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHeptanoic Acids --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors --therapeutic useen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshPyrroles --therapeutic useen_US
dc.titleEffect of chitosan on lipid levels when administered concurrently with atorvastatin--a placebo controlled study.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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