In vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain.

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dc.contributor.authorKumar, Ren_US
dc.contributor.authorBansal, R Cen_US
dc.contributor.authorMahmood, Aen_US
dc.date.accessioned1994-11-01en_US
dc.date.accessioned2009-05-27T06:51:38Z
dc.date.available1994-11-01en_US
dc.date.available2009-05-27T06:51:38Z
dc.date.issued1994-11-01en_US
dc.description.abstractIsatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro. At millimolar concentrations (1-10 mM) it inhibited brain acetylcholinesterase (AChE) and sodium, potassium-adenosine triphosphatase (Na+, K(+)-ATPase) activity also. However, isatin did not affect these enzymes after both acute and chronic treatments in vivo. Administration of isatin to rats at 300 mg/kg body weight for 2 and 6 h significantly raised brain serotonin levels. Chronic treatment for 20 days resulted in enhanced brain glycolipids and plasmalogen levels. There was no change in the levels of 5-hydroxy indole acetic acid (5 HIAA), phospholipids, cholesterol and gangliosides under these conditions.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University, Chandigarh.en_US
dc.identifier.citationKumar R, Bansal RC, Mahmood A. In vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain. Indian Journal of Medical Research. 1994 Nov; 100(): 246-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/18242
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Chemistry --drug effectsen_US
dc.subject.meshCholinesterase Inhibitors --pharmacologyen_US
dc.subject.meshIsatin --pharmacologyen_US
dc.subject.meshLipids --analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMonoamine Oxidase Inhibitors --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshSerotonin --analysisen_US
dc.subject.meshSodium-Potassium-Exchanging ATPase --antagonists & inhibitorsen_US
dc.titleIn vivo effects of isatin on certain enzymes, lipids & serotonergic system of rat brain.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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