An Overview of Helicobacter Pylori and Diagnostic Methods

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dc.contributor.authorRahimkhani, Men_US
dc.contributor.authorMordadi, Aen_US
dc.date.accessioned2020-04-23T07:26:19Z
dc.date.available2020-04-23T07:26:19Z
dc.date.issued2019-08
dc.description.abstractHelicobacter pylori are a gram negative, spiral, micro-aerophilic and slow-growing organism with a length of 3 and a diameter of about half a micrometer. The bacterium also produces some enzymes, the most important of which are oxidase, catalase and urease. More than half of the world's people are infected with this bacterium. The bacteria are the main cause of diseases such as gastric ulcer and gastric and intestinal complaints. The incidence of infections with this bacterium in the countries of Europe and North America are 10 times higher than in other countries. Helicobacter pylori are basically a spiral bacterium, but it can also be transformed into a spherical shape that can also be survived and pathogenic and connects to the gastric mucosa. Several laboratory methods are available including invasive and non-invasive methods. Each test has its own characteristics, but is not complete on its own. Usually, several tests are used together, but this depends on our goal of testing. Invasive method is endoscopic biopsy of gastric mucosa and rapid urease test on biopsy sample. Noninvasive methods are included, serologic tests (IgM, IgG & IgA), breath urease test and examination of H. pylori antigens in the stool. In specialized laboratories PCR is also used to identify bacteria. Regarding the prevalence of gastrointestinal diseases and the lack of adequate knowledge in today's societies about this bacterium, this study was conducted with the aim of reviewing Helicobacter pylori and different diagnostic methods.en_US
dc.identifier.affiliationsFaculty of allied medical sciences, Tehran University of Medical Sciences, Tehran, Iranen_US
dc.identifier.affiliationsDepartment of Epidemiology, Pasteur Institute, Tehran, Iranen_US
dc.identifier.citationRahimkhani M, Mordadi A. An Overview of Helicobacter Pylori and Diagnostic Methods. International Journal of Applied Biology and Pharmaceutical Technology. 2019 Aug; 10(3): 22-34en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198217
dc.languageenen_US
dc.publisherInternational Journal of Applied Biology and Pharmaceutical Technologyen_US
dc.relation.issuenumber3en_US
dc.relation.volume10en_US
dc.source.urihttps://www.doi.org/10.26502/ijabpt.006en_US
dc.subjectHelicobacter pylorien_US
dc.subjectDiagnosis methodsen_US
dc.titleAn Overview of Helicobacter Pylori and Diagnostic Methodsen_US
dc.typeJournal Articleen_US
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