Role of immunophenotyping in characterisation of blast crisis of chronic myeloid leukemia--a study of 25 cases.

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dc.contributor.authorPadmanabhan, Ven_US
dc.contributor.authorVarma, Nen_US
dc.contributor.authorDash, Sen_US
dc.contributor.authorVarma, Sen_US
dc.date.accessioned1996-01-01en_US
dc.date.accessioned2009-05-29T12:36:31Z
dc.date.available1996-01-01en_US
dc.date.available2009-05-29T12:36:31Z
dc.date.issued1996-01-01en_US
dc.description.abstractThe blast cell populations of 25 patients of chronic myeloid leukemia in blast crisis (CML-BC) were studied for morphological, cytochemical and immunophenotypic features. The patients were divided into 6 broad groups based upon the pattern of surface marker positivity-myeloblastic, mixed myeloblastic, megakaryoblastic, mixed lineage, lymphoid and undifferentiated blast crisis. Myeloperoxidase (MPO), Sudan Black B (SBB) and Chloroacetate esterase (CAE) stains showed 100% specificity for the myelomonocytic lineage but the sensitivity was low. Periodic acid Schiff (PAS) stain was neither specific nor sensitive for the lymphoid lineage. Immunophenotyping as compared to morphologic and cytochemical assessment, was seen to be most useful for assigning a lineage to leukemic cells in CML-BC.en_US
dc.description.affiliationDepartment of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.en_US
dc.identifier.citationPadmanabhan V, Varma N, Dash S, Varma S. Role of immunophenotyping in characterisation of blast crisis of chronic myeloid leukemia--a study of 25 cases. Indian Journal of Pathology & Microbiology. 1996 Jan; 39(1): 13-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74771
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshBlast Crisis --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshT-Lymphocyte Subsets --classificationen_US
dc.titleRole of immunophenotyping in characterisation of blast crisis of chronic myeloid leukemia--a study of 25 cases.en_US
dc.typeJournal Articleen_US
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